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ModelsTLR4-NFkB-phospho-NF-kB signaling in BMDM
The model was constructed to describe TLR4 induced NF-κB activation in native bone marrow-derived macrophages. It included processes of ligand (lipopolysaccharide) recognition, formation of dimer receptor complex and further signal transduction through TRAF6/TAK1 complex that leads to the activation...
2019-03-27 | MODEL1809230001 | BioModels
ProteomicsProteomics analysis of primary mouse sarcomas post radiation therapy
- We revealed that inhibition of glutamine metabolism via genetic deletion or pharmacological inhibition of glutaminase (Gls1) radiosensitizes primary sarcomas in vivo. To delineate the potential mechanism(s) of radiosensitization post radiation therapy (RT), we performed proteomic analysis of Gls1+...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-03 | PXD050936 | Pride
Radiation therapy Sarcoma Glutaminase 
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