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ProteomicsPDCD6 modulates LC3-associated phagocytosis-mediated antimicrobial defense by regulating lactate metabolism
LC3-associated phagocytosis (LAP) is critical in host defense against invading pathogens, but the molecular mechanism for LAP activation is still unclear. Here, we find programmed cell death 6 (PDCD6) as a negative regulator of LAP. PDCD6 deficiency in mice and macrophages induces enhanced bacterici...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD056047 | Pride
Lactate Lap Pdcd6 
UnknownA novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release.
Not available
S-EPMC7883739 | biostudies-literature
ProteomicsSIRT3 acts as delactylase to suppress hepatocellular carcinoma development
Our integrative studies characterized SIRT3 as a delactylase to suppress HCC development, and the activation of SIRT3 might be a promising therapeutic mean for HCC.
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039202 |
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