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UnknownIdentification of Mitochondrial and Succinylation Modification-Related Gene Signature in Ischemic Stroke.
Not available
S-EPMC12367933 | biostudies-literature
ProteomicsTargeting Prolyl 3-hydroxylase 1 Inhibits Pancreatic Cancer Progression and Macrophage Immunity
Using transcriptome sequencing, proteomic analyses and engineered mouse model, we have revealed a novel and pivotal role of Prolyl 3-hydroxylase 1 (P3H1) in PDAC. The expression of P3H1 is elevated in PDAC and correlates with poor outcomes in human patients. The genetic deletion of P3H1 in KPC mouse...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD070325 | Pride
P3h1 Plk1 Chemotherapy Tumor microenvironment Pancreatic ductal adenocarcinoma 
MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
UnknownICCTax: a hierarchical taxonomic classifier for metagenomic sequences on a large language model.
Not available
S-EPMC12619997 | biostudies-literature
UnknownViTax: adaptive hierarchical viral taxonomy classification with a taxonomy belief tree on a foundation model.
Not available
S-EPMC11805961 | biostudies-literature
UnknownVisual detection of the human metapneumovirus using reverse transcription loop-mediated isothermal amplification with hydroxynaphthol blue dye.
Not available
S-EPMC3487928 | biostudies-literature
MetabolomicsPhosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the role...
2021-09-28 | MTBLS3485 | MetaboLights
UnknownRural-urban differences in health outcomes, healthcare use, and expenditures among older adults under universal health insurance in China.
Not available
S-EPMC7549821 | biostudies-literature
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
UnknownOrally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer.
Not available
S-EPMC8293278 | biostudies-literature
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