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MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
GenomicsGenome-wide map of H3K4me3 in HEK293 cells after PRDM9 expression
PRDM9 is a histone methyltransferase expressed in meiotic germ cells that determines the location of genetic recombination hotspots through binding of its allele-specific DNA binding domain. Here we characterize the genome-wide chromatin modification for two human PRDM9 alleles (A and C) in human ce...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-67673 | biostudies-arrayexpress
TranscriptomicsPronounced and Extensive Microtubule Defects in a Saccharomyces cerevisiae DIS3 Mutant
The recently proposed exozyme hypothesis posits that subunits of the RNA processing exosome assemble into structurally distinct protein complexes that function in disparate cellular compartments and RNA metabolic pathways. Here, in a genetic test of this hypothesis, we examine the role of Dis3 -- a...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-01 | E-GEOD-29018 | biostudies-arrayexpress
GenomicsCentromere-Like Regions in Budding Yeast
Accurate chromosome segregation requires centromeres (CENs), the chromosomal sites where kinetochores form, to bridge DNA and attach to microtubules. In contrast to most eukaryotes, Saccharomyces cerevisiae possesses sequence-defined point centromeres. Chromatin immunoprecipitation followed by seq...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-18 | E-GEOD-31466 | biostudies-arrayexpress
TranscriptomicsMetabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis
The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the tumor epithelium are poorly understood. The signaling adapter p62 has been implicated as a positive regulator of epithelial tumorigenesis; however, its role in the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-55587 | biostudies-arrayexpress
TranscriptomicsThe Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast
The experimental evolution of laboratory populations of microbes provides an opportunity to observe the evolutionary dynamics of adaptation in real time.Until very recently, however, such studies have been limited by our inability to systematically find mutations in evolved organisms.We overcome thi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-13435 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of zebrafish embryos after 96 h exposure to two subsequent concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12β-trihydroxy-androsta-4,6-diene-3,17-dione (THADD)
The aim of this mRNA expression profiling experiment was to screen for ecotoxicogenomic fingerprints in zebrafish (Danio rerio) embryos as aquatic vertebrate non-target model exposed to sublethal concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12...
ORGANISM(S): Danio rerio 
2021-10-11 | E-MTAB-10922 | biostudies-arrayexpress
GenomicsThe Ovarian Cancer Association Consortium Data Access Committee
Data Access Committee EGAC00001000616
EGAC00001000616 | EGA
TranscriptomicsmiRNA Expression In Maintenance and Differentiation of Human Embryonic Stem Cells
Recent advances in the study of human embryonic stem cells (hESCs) and induced-pluripotent stem cells (iPS) highlight their importance as both model systems for basic research and avenues for therapeutic applications. To gain better insight into these cells, a clearer understanding of their molecul...
ORGANISM(S): Homo sapiens 
2010-09-09 | E-GEOD-14473 | biostudies-arrayexpress
TranscriptomicsA Myc transcriptional program that is independent of EMT drives a poor prognosis tumor-propagating phenotype in HER2+ breast cancer
The HER2 (ERBB2) and MYC genes are commonly amplified genes in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self renewal and tumour propagating capability o...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-43730 | biostudies-arrayexpress
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