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TranscriptomicsGenomeâ??wide transcriptional profiling with spatial resolution identifies Bone Morphogenetic Protein signaling as essential regulator of zebrafish cardiomyocyte regeneration.
In contrast to mammals, zebrafish regenerate heart injuries via proliferation of cardiomyocytes located at the wound border. Here, we show that tomo-seq can be used to identify whole-genome transcriptional profiles of the injury zone, the border zone and the healthy myocardium. Interestingly, the bo...
ORGANISM(S): Danio rerio 
2016-01-11 | E-GEOD-74652 | biostudies-arrayexpress
TranscriptomicsDeficiency in glucose transporter 12 results in heart failure and a diabetic phenotype in zebrafish
Cardiomyopathies-associated metabolic pathologies (e.g. T2D and insulin resistance) are a leading cause of mortality. It is known that the association between the pathologies works in both directions, where heart failure can lead to metabolic derangements such as insulin resistance. This intricate c...
ORGANISM(S): Danio rerio 
2014-12-04 | E-GEOD-59683 | biostudies-arrayexpress
UnknownSpatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate.
Not available
S-EPMC5815850 | biostudies-literature
UnknownEarly endocardial morphogenesis requires Scl/Tal1.
Not available
S-EPMC1950955 | biostudies-literature
UnknownThe zebrafish cohesin protein Sgo1 is required for cardiac function and eye development.
Not available
S-EPMC9545960 | biostudies-literature
TranscriptomicsGenome-wide RNA tomography in the zebrafish embryo
Advancing our understanding of embryonic development is heavily dependent on identification of novel pathways or regulators. While genome-wide techniques such as RNA sequencing are ideally suited for discovering novel candidate genes, they are unable to yield spatially resolved information in embryo...
ORGANISM(S): Danio rerio 
2014-10-23 | E-GEOD-59873 | biostudies-arrayexpress
UnknownA Heterozygous Mutation in Cardiac Troponin T Promotes Ca2+ Dysregulation and Adult Cardiomyopathy in Zebrafish.
Not available
S-EPMC8072640 | biostudies-literature
UnknownLive imaging of adult zebrafish cardiomyocyte proliferation ex vivo.
Not available
S-EPMC8489017 | biostudies-literature
UnknownEssential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
Not available
S-EPMC517514 | biostudies-literature
UnknownThe ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.
Not available
S-EPMC186448 | biostudies-literature
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