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GenomicsIdentification of N6-adenine methylation in C. elegans DNA
In mammalian cells, DNA methylation on the 5th position of cytosine (5mC) plays an important role as an epigenetic mark. However, DNA methylation was considered to be absent in C. elegans because of the lack of detectable 5mC as well as homologs of the cytosine DNA methyltransferases. Here, using mu...
ORGANISM(S): Caenorhabditis elegans 
2015-05-05 | E-GEOD-66504 | biostudies-arrayexpress
GenomicsChIPseq examination of EAP-1 binding across generations of spr-5(by101) mutant worms
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans Histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here we identifie...
ORGANISM(S): Caenorhabditis elegans 
2014-04-08 | E-GEOD-52102 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in human Bronchial Alveolar Lavage Cell (BAL) cell pellets
Clinical subphenotypes of asthma are characterized by pathological, cellular, and molecular heterogeneity of the airway. Gene expression profiling of airway inflammatory cells in diseased patients by microarray analysis will provide insight into the molecular heterogeneity and support the developmen...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-74986 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of untreated mouse lung broncheolar lavage samples (part of wider carcinogenesis study)
This SuperSeries is composed of the following subset Series:; GSE7244: Expression data from AJ mouse control lung tissue; GSE7258: Expression data of bronchoalveolar lavage cells from control or urethane treated AJ mice Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal mouse lung from age matched untreated controls from AJ mice were from two time points 24 to 26 weeks (N) or 42 weeks (N42) after saline injection
AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis to identify a unique macrophage expression signature in the lung tumor microenvironment. Experiment Overall Design: RNA from lung tissu...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7244 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bronchoalveolar lavage cells from AJ mice treated with urethane vs. controls
AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis of bronchoalveolar lavage cells from control or urethane treated mice. A unique macrophage expression signature in the lung tumor micro...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7258 | biostudies-arrayexpress
TranscriptomicsBlockade of thymic stromal lymphopoietin receptor (TSLPR) reduces allergic inflammation in a cynomolgus monkey model of asthma
TSLP pathway blockade is a potential strategy for asthma treatment, as TSLP modulates cytokine production by mast cells and regulates the activation of dendritic cells (DCs), which prime the differentiation of naM-CM-/ve T cells into inflammatory Th2 cells. To assess the effect of TSLPR blockade on ...
ORGANISM(S): Macaca fascicularis 
2013-10-22 | E-GEOD-41329 | biostudies-arrayexpress
TranscriptomicsHistologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients
Gene expression in histologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients share a similar profile Introduction: We hypothesized that gene expression in histologically normal epithelium (NlEpi) would differ in breast cancer patients (HN) compared...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20437 | biostudies-arrayexpress
TranscriptomicsNotch signaling-dependent gene expression in the developing mouse lung
Transcriptional profiling of Control and RbpjkCNULL lungs from E18.5. For microarray profiling, total RNA from E18.5 lungs was submitted for labeling and hybridization (Mouse Gene 1.0 ST Whole Genome Array, Affymetrix) to the Boston University Microarray Core facility. Clara cells (CCs) are a morph...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-52926 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers [MeDIP analysis]
Embryogenesis is tightly regulated by multiple levels of epigenetic systems such as DNA methylation, histone modification, and chromatin remodeling. DNA methylation patterns are erased in primordial germ cells and in the interval immediately following fertilization. Subsequent reprogramming occurs...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32080 | biostudies-arrayexpress
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