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ProteomicsElucidation of the substrate specificity of the ABC transporter Tba uncovers an unsuspected role in the biosynthesis of glycopeptide antibiotics
In this project, the proximal proteins of the balhimycin transporter Tba in A. balhimycina were investigated in order to elucidate potential interaction partners. Tba is an ABC transporter, which is co-encoded with biosynthetic enzymes in the biosynthetic gene cluster of the glycopeptide antibiotic ...
ORGANISM(S): Bacteria Amycolatopsis balhimycina 
2025-05-07 | PXD054387 | Pride
Amycolatopsis balhimycina Glycopeptide antibiotics Balhimycin Abc transporter 
UnknownDifferential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations.
Not available
S-EPMC3004843 | biostudies-literature
UnknownIdentification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.
Not available
S-EPMC89325 | biostudies-literature
TranscriptomicsElucidation of the substrate specificity of the ABC transporter Tba uncovers an unsuspected role in the biosynthesis of glycopeptide antibiotics
Glycopeptide antibiotics (GPA) such as vancomycin and teicoplanin are essential last-resort antibiotics produced by actinomycetes. Their biosynthesis is encoded within biosynthetic gene clusters, also harboring genes for regulation, and transport. Diverse types of GPAs have been characterized that d...
ORGANISM(S): Amycolatopsis balhimycina 
2025-04-09 | GSE274067 | GEO
UnknownBiosynthesis of chloro-beta-hydroxytyrosine, a nonproteinogenic amino acid of the peptidic backbone of glycopeptide antibiotics.
Not available
S-EPMC515157 | biostudies-literature
UnknownUnveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis.
Not available
S-EPMC11960670 | biostudies-literature
UnknownThe VanRS Homologous Two-Component System VnlRSAb of the Glycopeptide Producer Amycolatopsis balhimycina Activates Transcription of the vanHAXSc Genes in Streptomyces coelicolor, but not in A. balhimycina.
Not available
S-EPMC5036315 | biostudies-literature
UnknownPhosphate-controlled regulator for the biosynthesis of the dalbavancin precursor A40926.
Not available
S-EPMC2168674 | biostudies-literature
GenomicsElucidation of the substrate specificity of the ABC transporter Tba uncovers an unsuspected role in the biosynthesis of glycopeptide antibiotics
Elucidation of the substrate specificity of the ABC transporter Tba uncovers an unsuspected role in the biosynthesis of glycopeptide antibiotics
PRJNA1144888 | ENA
UnknownGenome sequencing and annotation of Amycolatopsis azurea DSM 43854(T).
Not available
S-EPMC4536004 | biostudies-literature
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