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TranscriptomicsSTAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and BarrettM-bM-^@M-^Ys adenocarcinomas
Signal transducer and activator of transcription 3 (STAT3) is altered in several epithelial cancers and represents a potential therapeutic target. Here, STAT3 expression, activity and cellular functions were examined in two main histotypes of esophageal carcinomas. In situ, immunohistochemistry for ...
ORGANISM(S): Homo sapiens 
2013-06-16 | E-GEOD-47763 | biostudies-arrayexpress
MetabolomicsDefined microbiota modulates host metabolome and skeletal adaptation to diet-induced obesity

Background

The gut microbiota is increasingly recognized as a regulator of host metabolism and bone physiology. However, how microbial colonization integrates systemic metabolic cues with skeletal remodeling under metabolic stress remains unclear.

Results

We used germ-free (GF) ...

2025-11-25 | MTBLS13384 | MetaboLights
TranscriptomicsExpression data from mouse cumulus cells
Follicle stimulating hormone (FSH) and epidermal growth factor (EGF) are currently used on cumulus-oocyte complexes to mimic the luteinizing hormone surge in vitro and induce oocyte maturation and cumulus expansion. We have previously shown that addition of exogenous recombinant growth differentiati...
ORGANISM(S): Mus musculus 
2011-12-10 | E-GEOD-19327 | biostudies-arrayexpress
ModelsPC12 Cell Differentiation
The nerve growth factor NGF has been shown to cause cell fate decisions toward either differentiation or proliferation depending on the relative activity of downstream pERK, pAKT, or pJNK signaling. However, how these protein signals are translated into and fed back from transcriptional activity to ...
4775 | Cell Collective
TranscriptomicsST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis
Cell surface sialylation confers many roles in cancer biology including cell proliferation, invasiveness, metastasis and angiogenesis. We show here that ST3Gal1 sialyltransferase marks a self-renewing cellular fraction. Depletion of ST3GAL1 abrogates glioma cell growth and tumorigenicity. In contras...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-51395 | biostudies-arrayexpress
TranscriptomicsBoolean modeling reveals the necessity of transcriptional regulation for bistablity in PC12 Cell Differentiation
The nerve growth factor NGF has been shown to cause cell fate decisions towards either differentiation or proliferation depending on the relative activity of downstream pERK, pAKT or pJNK signaling. However, how these protein signals are translated into and fed back from transcriptional activity to ...
ORGANISM(S): Rattus norvegicus 
2016-03-23 | E-GEOD-74327 | biostudies-arrayexpress
TranscriptomicsST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis
Cell surface sialylation confers many roles in cancer biology including cell proliferation, invasiveness, metastasis and angiogenesis. We show here that ST3Gal1 sialyltransferase marks a self-renewing cellular fraction. Depletion of ST3GAL1 abrogates glioma cell growth and tumorigenicity. In contras...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-51411 | biostudies-arrayexpress
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
GenomicsBC
WTCCC1 project Breast cancer (BC) samples
EGAD00000000013 | EGA
GenomicsMS
WTCCC1 project Multiple Sclerosis (MS) samples
EGAD00000000012 | EGA
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