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TranscriptomicsProteomic and transcriptomic analyses of Dhh1 complexes reveals mitochondrial RNP complex association with yeast P-bodies
P-bodies (PB) are cytoplasmic RNP complexes that aggregate into foci when cells are exposed to stress. While the core components and stress response of PB and related RNP granules are conserved, it remains unclear how and why cells assemble mRNP complexes into granule foci during stress. We use mas...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-16 | E-GEOD-65989 | biostudies-arrayexpress
TranscriptomicsGenetic Landscape of Copy Number Alterations in Gastric Cancer
Genome-wide DNA copy number profiling of gastric tumors and matched non-maligant samples. The affymetrix SNP6 array was used to obtain DNA copy number profiles in 193 gastric tumors and 98 matched gastric non-malignant samples. Genomic DNA extracted from 193 gastric tumors and 98 matched gastric non...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-31168 | biostudies-arrayexpress
TranscriptomicsThe disparate twins: A comparative study of CXCR4 and CXCR7 in SDF-1M-NM-1-induced gene expression, invasion and chemosensitivity of colon cancer
In colorectal cancer, increased expression of the CXC chemokine receptor 4 (CXCR4) has been shown to provoke metastatic disease due to the interaction with its ligand stromal cell-derived factor 1 (SDF-1). Recently, a second SDF-1 receptor, CXCR7, was found to enhance tumor growth in solid tumors. A...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-40017 | biostudies-arrayexpress
TranscriptomicsAxl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib
Elevated expression and activity of the epidermal growth factor receptor (EGFR) is associated with development and progression of head and neck cancer (HNC) and a poor prognosis. Clinical trials with EGFR tyrosine kinase inhibitors (TKIs; eg. erlotinib) have been disappointing in HNC. To investigate...
ORGANISM(S): Homo sapiens 
2013-08-10 | E-GEOD-49135 | biostudies-arrayexpress
TranscriptomicsMERLION LUNG CANCER STUDY_2_DNA
East-Asian (EA) patients with Non Small Cell Lung Cancer (NSCLC) are associated with a high proportion of non-smoking women, EGFR activating somatic mutations, and clinical responses to tyrosine kinase inhibitors. We identify copy number alterations specific to EA and Western European (WE) NSCLCs an...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-33848 | biostudies-arrayexpress
TranscriptomicsRegulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7
Elevated expression and activity of the epidermal growth factor receptor (EGFR)/protein kinase B (Akt) signaling pathway is associated with development, progression and treatment resistance of head and neck cancer (HNC). Several studies have demonstrated that microRNA-7 (miR-7) regulates EGFR expres...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-40130 | biostudies-arrayexpress
TranscriptomicsIntegrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma
Salivary gland adenoid cystic carcinoma (ACC) is a rare malignancy amongst head and neck tumors that is poorly understood on a molecular level. We sought to perform a comprehensive approach for novel oncogene candidate screening under the control of promoter methylation in order to learn more about ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-25746 | biostudies-arrayexpress
TranscriptomicsComprehensive Characterization of 3D Models for Prostate Cancer Growth and Invasion in Laminin-rich Extracellular Matrix
Full title: Comprehensive Characterization of Three-Dimensional Models for Prostate Cancer Growth and Invasion in Laminin-rich Extracellular Matrix Prostate Cancer (PrCa) cells undergo acinar morphogenesis and spheroid formation in three-dimensional (3D) culture, supported by laminin-rich extracellu...
ORGANISM(S): Homo sapiens 
2010-12-06 | E-GEOD-19426 | biostudies-arrayexpress
TranscriptomicsMesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis
Expression data from Total RNA extracted from murine spleen. Sepsis was induced in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) flui...
ORGANISM(S): Mus musculus 
2010-11-22 | E-GEOD-24357 | biostudies-arrayexpress
TranscriptomicsCritical Role of Sphingolipid Pathway Components in Murine Radiation-Induced Lung Injury: Protection by Sphingosine-1-Phosphate Analogues
Clinically significant radiation-induced lung injury (RILI) is associated with significant morbidity and mortality and a common toxicity in patients administered thoracic radiotherapy. While the molecular etiology of RILI is poorly understood, we previously characterized a murine model of RILI in wh...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-25295 | biostudies-arrayexpress
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