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TranscriptomicsDistinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation
The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3CM-bM-^@M-^Sderived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-53463 | biostudies-arrayexpress
TranscriptomicsNucleosome driven transcription factor binding and gene regulation [microarray]
Elucidating the global function of a transcription factor implies the identification of its target genes and genomic binding sites. The role of chromatin in this context is unclear, but the dominant view is that factors bind preferentially to nucleosome-depleted regions, identified as DNaseI-hyperse...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41502 | biostudies-arrayexpress
GenomicsPhf19 links methylated lysine 36 of histone H3 to regulation of Polycomb activity [ChIP-Seq]
Polycomb group proteins are transcriptional repressors that play essential roles in regulating genes required for differentiation and embryonic development. The Polycomb repressive complex 2 (PRC2) contains the methyltransferase activity for lysine 27 on histone 3 (H3K27me3), which is a docking site...
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-41589 | biostudies-arrayexpress
GenomicsNucleosome driven transcription factor binding and gene regulation [ChIP-Seq]
Elucidating the global function of a transcription factor implies the identification of its target genes and genomic binding sites. The role of chromatin in this context is unclear, but the dominant view is that factors bind preferentially to nucleosome-depleted regions, identified as DNaseI-hyperse...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41466 | biostudies-arrayexpress
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