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ProteomicsProteome profiling of Bacillus subtilis stressed with the antibiotics tetracycline and chelocardin
Chelocardin is an atypical tetracycline and its mechanism of action is discussed controversially in literature. Therefore, we analyzed the bacterial response of Bacillus subtilis to chelocardin and as a control for classical tetracyclines to tetracycline by proteomic profiling. The induced marker pr...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2016-03-14 | PXD003439 | Pride
Bacillus subtilis tetracycline chelocardin 2d-page proteomics 
ProteomicsApplicability of chromatographic co-elution for antibiotic research
Identification of the molecular target is crucial for evaluating novel antibiotics. To support target identification, a label-free method based on chromatographic co-elution (TICC) has been developed previously. In TICC, an alteration in the elution profile of the target-bound drug compared to free ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-10-01 | PXD017640 | Pride
Essential proteins Bacillus subtilis Protein complexes Protein-protein interaction 
ProteomicsNot just an alternative nitrogenase: The Fe-nitrogenase system belongs to the NifA regulon in Rhodobacter capsulatus
The diazotrophic bacterium Rhodobacter capsulatus synthesizes a molybdenum nitrogenase and an alternative iron-only nitrogenase, enabling growth with molecular dinitrogen as sole nitrogen source. Regulation of nitrogen fixation was analyzed by proteome profiling of wild-type and mutant strains lacki...
ORGANISM(S): Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) 
2019-07-19 | PXD013515 | Pride
Mo-nitrogenase  fe-nitrogenase  nifa regulon  anfa regulon  rhodobacter 
ProteomicsAdaptive responses of Pseudomonas aeruginosa to treatment with antibiotics and non-steroidal anti-inflammatory drugs
Circumventing or overwhelming the bacterial adaptation capabilities is key to combatting multidrug-resistant pathogens like Pseudomonas aeruginosa. We investigated the physiological stress exerted by approved antibiotics (ciprofloxacin, levofloxacin, rifampicin, gentamicin, tobramycin, azithromycin,...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2022-08-12 | PXD022879 | Pride
Proteomics Lps biosynthesis inhibition Mode of action Stress response Pseudomonas aeruginosa 
ProteomicsProteome profiling of Rhodobacter capsulatus wild type and a ΔmodABC mutant in response to molybdenum
The diazotrophic bacterium Rhodobacter capsulatus is able to synthesize two nitrogenases, a molybdenum-dependent and an alternative Mo-free iron-only nitrogenase, enabling growth with molecular dinitrogen (N2) as sole nitrogen source. The Mo response of the wild type and a mutant lacking the high-af...
ORGANISM(S): Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) 
2015-12-14 | PXD003123 | Pride
Rhodobacter capsulatus molybdenum lc-ms proteomics mse 
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