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TranscriptomicsDissecting the mechanisms of syncytiotrophoblast regeneration using apical-out human placental organoids
The syncytiotrophoblast, the outer layer of the placental villus, is continuously shed into maternal blood and replaced by newly fused vCT. This process needs to be tightly regulated throughout pregnancy to ensure the health of the mother and the fetus. We developed apical-out first trimester placen...
ORGANISM(S): Homo sapiens 
2026-10-27 | E-MTAB-17218 | biostudies-arrayexpress
TranscriptomicsDissecting the mechanisms of syncytiotrophoblast regeneration using apical-out human placental organoids
The syncytiotrophoblast, the outer layer of the placental villus, is continuously shed into maternal blood and replaced by newly fused vCT. This process needs to be tightly regulated throughout pregnancy to ensure the health of the mother and the fetus. We developed apical-out first trimester placen...
ORGANISM(S): Homo sapiens 
2026-10-27 | E-MTAB-15647 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat primary cardiac myocytes treated with endothelin-1, cycloheximide, azekenpaullone or combinations of these before extraction of total or polysomal RNA
Ventricles were removed from 2-day Sprague_Dawley rat litters from which primary cardiac myocytes (>95%) were isolated. Myocytes were either untreated or exposed to either endothelin-1 for 30, 60 or 120 minutes, cycloheximide for 70 or 130 minutes, endothelin-1 for 10 minutes followed by cycloheximi...
ORGANISM(S): Rattus rattus 
2008-02-17 | E-MIMR-681 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse finally differentiated 3T3-L1 adipocytes treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours
Finally differentiated 3T3-L1 adipocytes are treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours to understand insulin and metformin(an anti-diabetic drug commonly applied for Non-Insulin Dependent Diabetes Mellitus)action in adipose tissues.
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-8 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse H-2Kb muscle cells treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours
The basic design of the experiment is as described in Fryer et al.(2000)Diabetes 49:1978, and is similar to proto-BAIR (EXP_BAIR_0603_02). H-2Kb muscle cells were treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours.
ORGANISM(S): Mus musculus 
2022-11-23 | E-BAIR-7 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of epidydimal fat pads in mice following high fat and normal diets to study insulin resistance and obesity
Gene transcription profiling in Epidydimal fat pad (EPD) following High fat versus normal diet in C57/Bl6 mice. Characterisation of molecular mechanisms of in vivo insulin action in mouse models of experimentally induced Insulin resistance. Switched the...
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-12 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver following high fat and normal diets to study insulin resistance and obesity
Gene transcription profiling in liver following high fat versus normal diet in C57/Bl6 mice. Characterisation of molecular mechanisms of in vivo insulin action in mouse models of experimentally induced Insulin Resistance. ...
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-10 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of epidydimal fat pads in mice at different time points following high fat and normal diets to study insulin resistance and obesity
Gene transcription profiling in Epidydimal fat pad (EPD) following High fat versus normal diet in C57/Bl6 mice. The diet was switched when mice were 5 weeks old, then samples taken at 2 days, 8 days, 3 weeks and 15 weeks.
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-9 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of muscle cells in mice at different different time points following muscle and normal diets to study insulin resistance and obesty
Gene transcription profiling in muscle following muscle versus normal diet in C57/Bl6 mice. Switched the diet when mice were 5 weeks old, then sampled at 8 days, 3 weeks and 15 weeks.
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of H2O2 treated rat cardiac myocytes
Title: Changes in gene expression affected by H2O2 in cardiac myocytes.
Description: We aim to identify the changes in gene expression in response to
oxidative stress in rat neonatal ventricular myocytes.
Oxidative stress will be induced by dosing neonatal ventricular myocyte...
ORGANISM(S): Rattus norvegicus 
2011-11-08 | E-MIMR-12 | biostudies-arrayexpress
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