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The 2009 H1N1 influenza pandemic has prompted a significant need for the development of efficient, single-dose, adjuvanted vaccines. Here we investigated the adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG...
ORGANISM(S): Mustela putorius furo 
Pandemic H1N1 influenza A Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but significant number of infected individuals. Microarray analysis of the lymph nodes from ferrets infected with A/California/07/2009 shows intense gene u...
ORGANISM(S): Mustela putorius furo 
Background: Pandemic H1N1 influenza A is a newly emerging strain of human influenza that is easily transmitted between people and has spread globally to over 116 countries. Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but sign...
ORGANISM(S): Mustela putorius furo 
Profile of host response in C57BL6/J mice infected with A/Mexico/4108/2009 (H1N1), spanning days 1 through 6 post-infection. Focused analysis on the involvement of IL-6 in the host response. Total RNA obtained from lung tissue collected from infected C57BL6/J mice at t = 1, 2, 3, 4, 5, 6 days post-...
ORGANISM(S): Mus musculus 
Critical disease caused by the new 2009 pandemic influenza virus (nvH1N1) is a challenge for physicians and scientist. As evidenced in SARS and H5N1, the development of an effective immune response plays a key role to overcome viral diseases. We studied host`s gene expression signatures, cytokine a...
ORGANISM(S): Homo sapiens 
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