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ProteomicsTranscriptomic and proteomic profiling of non-classical monocytes unravels distinct pathogenic features in SLE
Current non-specific immunosuppressive treatments for Systemic Lupus Erythematosus (SLE) show modest efficacy. In SLE the monocytic/macrophage (Mo/Mφ) system plays a key role in the initiation and perpetuation of the systemic autoimmune response. However, the distinct functions of the Mo/Mφ cellular...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD042539 | Pride
Proteomics Non-classical monocytes Differentiation Cytokines M1 macrophages Autoimmunity Cell cycle Transcriptomics Systemic lupus erythematosus 
TranscriptomicsATAC-seq examining chromatin accessibility of mouse splenic IL-10+ and IL-10-CD19+CD21hiCD24hi B cells
Chromatin profiling of mouse splenic ex-vivo IL-10+, IL-10-CD19+CD21hiCD23hiCD24hi B cells and IL-10- follicular B cells, after antigen induced arthritis. IL-10eGFP reporter (Vert-X) mice were used to sort IL-10+ and IL-10- subsets. ATAC-seq was used in conjunction with microarray data to understand...
ORGANISM(S): Mus musculus 
2019-10-09 | E-MTAB-8393 | biostudies-arrayexpress
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