Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse VP16-CREB transgenics
Expression of VP16-CREB, a constitutively active form of CREB, in hippocampal neurons of the CA1 region lowers the threshold for eliciting the late, persistent phase of long-term potentiation (L-LTP) in the Schaffer collateral pathway. This VP16-CREB-mediated L-LTP differs from the conventional late...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3965 | biostudies-arrayexpress
TranscriptomicsUltrastructural and transcriptional profiling of neuropathological misregulation of CREB function
We compare here the neurodegenerative processes observed in the hippocampus of bitransgenic mice with chronically altered levels of cAMP-response element-binding protein (CREB) function. The combination of genome-wide transcriptional profiling of degenerating hippocampal tissue with microscopy analy...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21137 | biostudies-arrayexpress
GenomicsGenomic topography of HDACi-induced hyperacetylation of hippocampal chromatin [ChIP-Seq]
Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory and synaptic plasticity and to ameliorate cognitive deficits and degeneration in animal models for different neuropsychiatric conditions. However, the impact of these drugs on hippocampal histone acety...
ORGANISM(S): Mus musculus 
2013-07-09 | E-GEOD-43439 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of neural HDAC inhibition
Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory and synaptic plasticity and to ameliorate cognitive deficits and degeneration in animal models for different neuropsychiatric conditions. However, the impact of these drugs on hippocampal histone acety...
ORGANISM(S): Mus musculus 
2013-07-09 | E-GEOD-43051 | biostudies-arrayexpress
TranscriptomicsGene expression profile of N171-HD82Q hippocampus and cerebellum.
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44306 | biostudies-arrayexpress
GenomicsGenomic landscape of transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington's disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44855 | biostudies-arrayexpress
GenomicsHistone deacetylation-dependent and -independent transcriptional dysregulation in early-onset polyglutamine disease
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44854 | biostudies-arrayexpress
TranscriptomicsCBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.
The epigenetic changes of the chromatin represent an attractive molecular substrate for adaptation to the environment. We examined here the role of CBP, a histone acetyltransferase involved in mental retardation, in the genesis and maintenance of long-lasting systemic and behavioral adaptations to e...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-30880 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis of Wild Type and Dicer1-ifKO Hippocampal Transcriptomes (mRNA and small RNA) Through Next Generation Sequencing (mRNA-Seq).
Methods: CaMKIIa-creERT2 (Erdmann et al., 2007) and Dicer1f/f (Harfe et al., 2005) were crossed to produce inducible forebrain-restricted Dicer1 knockout mice (Dicer-ifKO) mice. Hippocampal mRNA profiles of 3-month-old wild-type (WT) and (Dicer-ifKO) mice were generated by deep sequencing, in tripli...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-60261 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis of Wild Type and Dicer1-ifKO Hippocampal Transcriptomes (mRNA and small RNA) Through Next Generation Sequencing (smallRNA-Seq).
Methods: CaMKIIa-creERT2 (Erdmann et al., 2007) and Dicer1f/f (Harfe et al., 2005) were crossed to produce inducible forebrain-restricted Dicer1 knockout mice (Dicer-ifKO) mice. Hippocampal small RNA profiles of 3-month-old wild-type (WT) and (Dicer-ifKO) mice were generated by deep sequencing, in t...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-60262 | biostudies-arrayexpress
Sort   by:  
 Page size