Sort   by:  
 Page size 
TranscriptomicsAirway Epithelial miRNA Expression in Asthma
We performed genome-wide profiling of miRNA expression in the airway epithelial compartment in asthma to identify miRNA pathways associated with epithelial abnormalities using miRNA microarrays and real-time PCR. We also sought to identify the effect of inhaled corticosteroids (ICS) on airway epithe...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-34466 | biostudies-arrayexpress
TranscriptomicsmiRNA expression during in vitro mouse T cell activation (CD T cell timecourse)
Array of global miRNA expression during a time course of in vitro CD4 T cell activation 50 ng RNA isolated from mouse CD4 T cells, activated in vitro for a time course spanning 7 days and restimulated
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-36606 | biostudies-arrayexpress
TranscriptomicsThe protein disulfide isomerase AGR2 is essential for the production of intestinal mucus
Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals but the roles of specific PDIs in vivo are poorly understood. A recent hom...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12503 | biostudies-arrayexpress
TranscriptomicsmiRNA expression during in vitro mouse T cell activation (D011.10+ CD4 T cells)
Array of global miRNA expression during an in vivo effector and anergic T cell response 250 ng RNA isolated from mouse D011.10+ CD4 T cells, activated in vivo for 5 days
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-36607 | biostudies-arrayexpress
TranscriptomicsDifferential Effects of TiO2 Nanotubes on Vascular Cells
The response of primary human endothelial (ECs) and vascular smooth muscle cells (VSMCs) to TiO2 nanotube arrays is studied through gene expression analysis. Microarrays revealed that nanotubes enhanced EC proliferation and motility, decreased VSMC proliferation, and decreased expression of molecul...
ORGANISM(S): Homo sapiens 
2010-08-14 | E-GEOD-17676 | biostudies-arrayexpress
TranscriptomicsMechanisms of TGFB1 induced atrial fibrosis
This project aims to compare gene expression in transgenic mice that overexpress TGFB1 to wild type mice. Transgenic mice have a fibrotic response in the atria, but not the ventricle. This is a 2 color design; dye swaps and a loop design were incorporated. Each group has N=4, with the exception bein...
ORGANISM(S): Mus musculus 
2014-01-31 | E-GEOD-27133 | biostudies-arrayexpress
TranscriptomicsComparison of Bleo, Asthma, TH2 and Infection Models
Disease-Specific Gene Expression Profiling in Multiple Models of Lung Disease We profiled lung gene expression in 12 mouse models of infection, allergy, and lung injury. A total of 24 transcripts, including many involved in inflammation and immune activation, were differentially expressed in a subs...
ORGANISM(S): Mus musculus 
2006-12-30 | E-GEOD-4231 | biostudies-arrayexpress
TranscriptomicsHuman bronchial epithelial cells_Passage 3 vs. passage 0
Squamous metaplasia is common in smokers and is associated with airway obstruction in chronic obstructive pulmonary disease (COPD). A major mechanism of airway obstruction in COPD is thickening of the small airway walls. We asked whether squamous metaplasia actively contributes to airway wall thicke...
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-7557 | biostudies-arrayexpress
TranscriptomicsDrug screening for Dravet syndrome using Scn1a zebrafish mutants
Severe myoclonic epilepsy of infancy (SMEI), or Dravet syndrome (DS), is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development, and persistent drug-resistant seizures. One of its primary monogenic causes is a mutation in SCN1A (Nav1.1), a type I voltage-...
ORGANISM(S): Danio rerio 
2014-01-04 | E-GEOD-43312 | biostudies-arrayexpress
TranscriptomicsmiRNA measurements in wildtype and Eri1-deficient Th cells
Natural killer (NK) cells play a critical role in early host defense to infected and transformed cells. Here we show that mice deficient in Eri1, a conserved 3M-bM-^@M-^Y-to-5M-bM-^@M-^Y exoribonuclease that represses RNA interference, have a cell-intrinsic defect in the homeostasis and terminal mat...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-32126 | biostudies-arrayexpress
Sort   by:  
 Page size