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ProteomicsPLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
The PIP3/PI3K network is a central regulator of metabolism and is frequently activated in cancer, commonly by loss of the PIP3/PI(3,4)P2-phosphatase, PTEN. Despite huge investment, the drivers of the PI3K network in normal tissues and how they adapt to overactivation are unclear. We find that in hea...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-23 | PXD043239 | Pride
Irs1 Pten Plekhs1 Prostate Pi3k 
TranscriptomicsPancreatic ductal adenocarcinoma primary cultures enriched or not in cancer stem cells
RNA sequencing of pancreatic ductal adenocarcinoma (PDAC) primary cultures from five different patient-derived xenograft models grown either in adherent conditions selecting for non-CSCs or in CSC-enriching anchorage-independent sphere conditions. A and B are two biological duplicates, from the same...
ORGANISM(S): Homo sapiens 
2015-11-01 | E-MTAB-3808 | biostudies-arrayexpress
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