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MetabolomicsLipidomics dataset of PTEN deletion-induced nerve regeneration mouse model
Not available
ORGANISM(S): Mus musculus 
ST001477 | MetabolomicsWorkbench
ProteomicsInhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
Glioblastoma (GBM) is the most lethal brain tumour that occurs in adults and treatment for GBM has been largely unsuccessful. Ionizing radiation (IR) and chemotherapeutic agents are employed as standard of care treatment for GBM patients and both result in DNA damage. Previous data identified phosph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-07 | MSV000081423 | MassIVE
TranscriptomicsTranscription profiling of mouse model of intestinal polyposis PTEN-deficient mutant reveals intestinal stem cells initiate intestinal polyposis
Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts. Crypts contain intestinal stem cells (ISCs). Thus intestinal polyposis provides an ideal condition for studying stem cell involvement in polyp/tumor formation. Using a conditional kno...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6078 | biostudies-arrayexpress
TranscriptomicsHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Gene expression of hepatocyt-specific knockout of Pten and of Pten and Tgfbr2 in mice as a model for human cholangiocarcinoma was determined Affymetrix Mouse 1.0ST chips were used to measure gene expression Gene expression of the following mouse livers were characterized A. WT (n=3). B. Pten-/- (n...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-66717 | biostudies-arrayexpress
ProteomicsPTEN DEFICIENCY LEADS TO PROTEASOME ADDICTION, A NOVEL VULNERABILITY IN GLIOBLASTOMA
Glioblastoma (GBM) is the most common primary brain tumor in adults with a median survival of approximately 15 months, therefore, more effective treatment options for GBM are required. To identify new drugs targeting glioblastomas, we performed a high throughput drug screen using patient-derived neu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-04 | MSV000086560 | MassIVE
TranscriptomicsBiallelic and complicated inactivation of Pten in radiation-induced mouse thymic lymphomas
Inactivation of Pten occurs by multiple mechanisms including epigenetic silencing, point mutations, insertion, and deletion, which are tissue dependent. Although frequent loss of heterozygosity around Pten locus and plausible involvement of epigenetic silencing have been reported in radiation-induce...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-17751 | biostudies-arrayexpress
ProteomicsMCF-7 PTEN-Nedd8 IP-MS
We intended to elucidate the underlying mechanism of PTEN-Nedd8 in tumorigenesis. So, we firstly employed affinity purification and mass spectrometry to interrogate PTEN-Nedd8 interactome in nucleus.
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD011395 | Pride
Human Breast cancer cell Nedd8 Pten Ip-ms 
TranscriptomicsTranscription profiling of human HCT116 PTEN+/+ cell lines and three independently-derived HCT116 PTEN-/- cell lines
In an effort to identify genes whose expression is regulated by activated PI3K signaling, we performed microarray analysis and subsequent qRT-PCR on an isogenic set of PTEN gene-targeted human cancer cells. Numerous p53 effectors were upregulated following PTEN deletion, including p21, GDF15, PIG3, ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6263 | biostudies-arrayexpress
ProteomicsElucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction
PTEN (Phosphatase and TENsin homolog deleted on chromosome ten) is a major tumor suppressor gene that is frequently mutated or lost under cancerous conditions. PTEN is a dual-specificity phosphatase that negatively regulates the PI3K/AKT/mTOR signaling pathway at the plasma membrane (PM). Its functi...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD059974 | Pride
Molecular dynamics Molecular modeling Molecular biology Conformational change Rasp stability prediction Crosslinking mass spectrometry (xl-ms) Alphamissense Clinical mutation Integrative structural modeling Phosphatase and tensin homolog (pten) 
ProteomicsPTENε, a new isoform of PTEN, suppresses tumor metastasis through filopodia formation regulation.
PTEN is frequently mutated in a wide range of malignancies. Beyond suppressing tumorigenesis, PTEN is involved in multiple biological processes, and the complexity of PTEN function is partially attributed to PTEN family members including PTENα and PTENβ. Here, we report the identification of PTENε (...
ORGANISM(S): Homo sapiens (Human) 
2021-01-11 | PXD022245 | Pride
Alternative initiation/filopodia formation/ptenε/pten isoform/metastasis. 
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