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UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
TranscriptomicspCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsal striatum
Neuroplastic changes in the dorsal striatum participate in the transition from casual drug use to habitual and compulsive drug taking. These alterations might also play a critical role in the development of methamphetamine (METH) addiction. Nevertheless, the molecular substrates that underlie habitu...
ORGANISM(S): Rattus norvegicus 
2012-05-31 | E-GEOD-38223 | biostudies-arrayexpress
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Moemory in Alzheimer's Disease Mice
Here, we present findings from our drug discovery program to identify small molecules that enhance sCLU levels and assess their impact on AD pathology and cognition in a murine model of AD. A high-throughput screening campaign identified two classes of epigenetic modulators that increase sCLU levels...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060173 | Pride
Epigenetic modulator Alzheimer's disease Memory improvement Secreted clustering enhancer 
TranscriptomicsSignatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study
We performed whole blood transcriptome analysis on a total of 70 critically injured patients (Injury Severity Score [ISS] >25) in the hyperacute time period within 2 hours of injury, at 24h and again at 72h. We compared transcriptome findings in 36 critically injured patients with those of 6 patient...
ORGANISM(S): Homo sapiens 
2017-07-06 | E-MTAB-5882 | biostudies-arrayexpress
UnknownChronic alcohol consumption shifts learning strategies and synaptic plasticity from hippocampus to striatum-dependent pathways.
Not available
S-EPMC10250670 | biostudies-literature
UnknownA therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice.
Not available
S-EPMC11331084 | biostudies-literature
UnknownPhospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.
Not available
S-EPMC12208538 | biostudies-literature
UnknownTargeted Transcriptomic Analysis of C57BL/6 and BALB/c Mice During Progressive Chronic Toxoplasma gondii Infection Reveals Changes in Host and Parasite Gene Expression Relating to Neuropathology and Resolution.
Not available
S-EPMC8012756 | biostudies-literature
TranscriptomicsRNA-seq of a controlled porcine model of trauma and haemorrhagic shock treated by fluid resuscitation against untreated controls
This was a randomised study in terminally anaesthetised female cross-bred Large White pigs. Initially, animals were anaesthetised and instrumented for continuous physiological monitoring and sampling; blood samples were collected upon initiation of the surgery (line-in, T = -150 minutes). Following ...
ORGANISM(S): Sus scrofa 
2026-10-28 | E-MTAB-16011 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profiling of the Igf2 pathway dependency of Trp53 developmental and tumour phenotypes in mice
We tested whether loss of p53 function leads to insulin-like growth factor 2 (IGF2) pathway dependency in vivo in genetically defined mouse models. Unexpectedly we found lethality, due to post-natal lung haemorrhage, occurred in Igf2 paternal null allele female mice (Igf2-p) but only if derived from...
ORGANISM(S): Mus musculus 
2012-06-01 | E-MTAB-1001 | biostudies-arrayexpress
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