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ProteomicsA novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. It has been proposed as an actionable target to alleviate the loss of function of the mitophagy pathway governed by the Parkinson’s Disease associated genes PINK1 and PRKN. We present the cha...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD018640 | Pride
Ubiquitylome Mitophagy Lc-ms Deubiquitylase Usp30 Parkinson’s disease Dub inhibitor Ubiquitin 
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