Sort   by:  
 Page size 
ModelsBarr2016 - All-or-nothing G1/S transition
Barr2016 - All-or-nothing G1/S transition This model is described in the article: A Dynamical Framework for the All-or-None G1/S Transition. Barr AR, Heldt FS, Zhang T, Bakal C, Novák B. Cell Syst 2016 Jan; 2(1): 27-37 Abstract: The transition from G1 into DNA replica...
2024-09-02 | BIOMD0000000646 | BioModels
ModelsBarr2017 - Dynamics of p21 in hTert-RPE1 cells
Barr2017 - Dynamics of p21 in hTert-RPE1 cells This deteministic model reveals that a bistable switch created by Cdt2, promotes irreversible S-phase entry by keeping p21 levels low, prevents premature S-phase exit upon DNA damage This model is described in the article: DNA damage during S-...
2024-09-02 | BIOMD0000000660 | BioModels
ModelsHeldt2018 - Proliferation-quiescence decision in response to DNA damage
Heldt2018 - Proliferation-quiescence decision in response to DNA damage This model is described in the article: A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells. ...
2024-09-02 | BIOMD0000000700 | BioModels
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
TranscriptomicsLarge-scale temporal gene expression profiling during gonadal differentiation and early gametogenesis in rainbow-trout
Animals and samplings: Research involving animal experimentation has been approved by the author's institution (authorization number 35-14) and conforms to NIH guidelines. All-male and all-female rainbow trout populations were obtained from the INRA experimental fish farm (Drennec, France) using bre...
ORGANISM(S): Oncorhynchus mykiss 
2005-06-01 | E-GEOD-2151 | biostudies-arrayexpress
TranscriptomicsImpact of regulatory variation from mRNA to protein
Genetic variants that impact gene regulation are important contributors to human phenotypic variation. For this reason, considerable efforts have been made to identify genetic associations with differences in mRNA levels of nearby genes, namely, cis expression quantitative trait loci (eQTLs). The ph...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-61742 | biostudies-arrayexpress
Sort   by:  
 Page size