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TranscriptomicsGenomic analysis of diffuse pediatric low-grade gliomas identifies recurrent, oncogenic MYBL1-truncating rearrangements
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but apart from BRAF mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are therefore especiall...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-45843 | biostudies-arrayexpress
TranscriptomicsConserved and Essential Transcription Factors for Cellulase Gene Expression in Ascomycete Fungi.
Transcriptional profiling with next-generation sequencing methods refined our understanding of the N. crassa transcriptional response to cellulose and demonstrated that the newly characterized transcription factors clr-1 and clr-2 were required for the bulk of that response including induction all m...
ORGANISM(S): Neurospora crassa OR74A 
2012-04-23 | E-GEOD-35227 | biostudies-arrayexpress
TranscriptomicsRole of a GntR-family response regulator LbrA in Listeria monocytogenes biofilm formation
The formation of Listeria monocytogenes biofilms contributes to persistent contamination in food processing facilities. A microarray comparison of L. monocytogenes between the transcriptome of the strong biofilm forming strain (Bfms) Scott A and the weak biofilm forming (Bfmw) strain F2365 was condu...
ORGANISM(S): Listeria monocytogenes 
2012-09-06 | E-GEOD-40598 | biostudies-arrayexpress
TranscriptomicsHigh-throughput pyrosequencing of endogenous small RNAs from CSR-1 IP complexes and csr-1(tm892) and ego-1(om97) mutants
High-throughput pyrosequencing of endogenous small RNAs from CSR-1 IP complexes and csr-1(tm892) and ego-1(om97) mutants with corresponding controls. RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CS...
ORGANISM(S): Caenorhabditis elegans 
2009-10-02 | E-GEOD-18165 | biostudies-arrayexpress
TranscriptomicsCSR-1 mediates RNA activation, RNAa, a self-RNA recognition pathway that promotes gene expression in the C. elegans germline
Epigenetic inheritance is the transmission of information independently of the nucleotide sequence of the genome. A fundamental question in biology is to what extent does epigenetics contribute to trans-generational inheritance. Here we investigate the role of Argonaute-small-RNA pathways in epigen...
ORGANISM(S): Caenorhabditis elegans 
2013-12-23 | E-GEOD-49532 | biostudies-arrayexpress
TranscriptomicsReliability and stability of individual differences in gene expression
Studying the causes and correlates of natural variation in gene expression in healthy populations assumes that individual differences in gene expression can be reliably and stably assessed across time. However, this is yet to be established. We examined 4-hour test-retest reliability and 10 month te...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-14844 | biostudies-arrayexpress
TranscriptomicsHigh throughput sequencing of endogenous small RNAs from AGO pathway mutants
High-throughput pyrosequencing of endogenous small RNAs from >95% male enriched populations of alg-3(tm1155);alg-4(ok1041);fog-2(q71) and fog-2(q71) worms as well as purified spermatids from fem-3(q20) adult worms. Gametogenesis is thermosensitive in numerous metazoa ranging from worms to man. In C...
ORGANISM(S): Caenorhabditis elegans 
2010-02-24 | E-GEOD-18729 | biostudies-arrayexpress
UnknownThe influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation.
Not available
S-EPMC7171750 | biostudies-literature
TranscriptomicsTranscript profiling of tomato mutants producing anthocyanins in the fruit
Anthocyanins are high value plant antioxidants which are not present in the fruits of cultivated tomato. However, both the dominant gene Anthocyanin fruit (Aft) and the recessive gene atroviolacea (atv), introgressed into domesticated tomato from two different wild Solanum species, stimulate a limit...
ORGANISM(S): Solanum lycopersicum 
2010-07-30 | E-GEOD-19792 | biostudies-arrayexpress
UnknownDevelopment of multiplex PCRs for detection of common viral pathogens and agents of congenital infections.
Not available
S-EPMC1248455 | biostudies-literature
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