Sort   by:  
 Page size 
MetabolomicsDoes Storage Post Sampling Influence the Stability of Sebum when used for Mass Spectrometry Metabolomics Analysis?

Sebum is a biofluid excreted by sebaceous glands in the skin. In recent years sebum has been shown to contain endogenous metabolites diagnostic of disease, with remarkable results for Parkinson’s Disease. Given that sebum sampling is facile and non-invasive, its potential for use in clinical bioc...

2025-07-15 | MTBLS7946 | MetaboLights
MetabolomicsMetabolomics of sebum reveals lipid dysregulation in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum,...
2020-12-21 | MTBLS2266 | MetaboLights
ProteomicsHybrid mass spectrometry applied across the production of antibody biotherapeutics.
Post expression from the host cell, a bio-therapeutic will be subjected to several downstream processing steps prior to final formulation. Analysis of the product under various buffer conditions at each stage is desirable to show that the integrity of the sample is maintained and to monitor any pote...
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD051563 | Pride
Dynamics Purification stages Monoclonal antibody Hdx-ms Formulation Perfusion media 
MetabolomicsMetabolomic Changes in Idiopathic and GBA1 Parkinson’s Disease

Background Variants in the β-glucocerebrosidase (GBA1) gene are the commonest genetic risk factor for Parkinson Disease (PD). Here, we use mass spectrometry based metabolomics to analyse serum and sebum samples from 50 genotyped participants and find differences in lipid and sugar reg...

2025-09-18 | MTBLS10743 | MetaboLights
MetabolomicsClassification of Parkinson’s Disease and Delineating Progression Markers from the Sebum Volatilome

Parkinson's Disease (PD) has been associated with a distinct odour, which emanates from the skin and is strongest in sebum-rich areas. In this study, sebum was sampled from participants using cotton gauze and the volatile components emanating from these swabs were analysed directly with thermal d...

2025-07-15 | MTBLS11712 | MetaboLights
MetabolomicsInvestigating the effects of circadian rhythm on the human skin lipidome

The circadian rhythm is a 24 h cycle that harmonises the activity of organs – including the skin – to a daily routine using neurological and hormonal signals. Limited research has been done to understand the effects of the circadian rhythm on the skin lipidome. We used reverse...

2025-10-17 | MTBLS12607 | MetaboLights
Sort   by:  
 Page size