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TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
TranscriptomicsInflammasome-dependent Interferon-gamma drives pathogenesis in Streptococcus pneumoniae meningitis.
A comparison of brain gene expression profiles in wildtype mice and interferon gamma -/- mice during bacterial meningitis.
ORGANISM(S): Mus musculus 
2012-09-01 | E-MEXP-3697 | biostudies-arrayexpress
TranscriptomicsTherapeutic targeting of myeloid leukemias with spliceosomal mutations through modulation of splicing catalysis
Mutations in spliceosomal genes are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These mutations occur at highly restricted amino acid residues and perturb normal splice site and exon recognition. Spliceosomal mutations are always heterozygous and...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-74064 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat primary cardiac myocytes treated with endothelin-1, cycloheximide, azekenpaullone or combinations of these before extraction of total or polysomal RNA
Ventricles were removed from 2-day Sprague_Dawley rat litters from which primary cardiac myocytes (>95%) were isolated. Myocytes were either untreated or exposed to either endothelin-1 for 30, 60 or 120 minutes, cycloheximide for 70 or 130 minutes, endothelin-1 for 10 minutes followed by cycloheximi...
ORGANISM(S): Rattus rattus 
2008-02-17 | E-MIMR-681 | biostudies-arrayexpress
TranscriptomicsExpression data from primary and secondary CD4 T cell effectors responding towards influenza A virus infection
How secondary CD4 T cell effectors, derived from resting memory cells, differ from primary cells, derived from naïve precursors, and how such differences impact recall responses to pathogens is unknown. We used microarrays to detail the global programme of gene expression underlying differences betw...
ORGANISM(S): Mus musculus 
2012-08-27 | E-GEOD-40230 | biostudies-arrayexpress
GenomicsRegulation of chromatin structure by Set1 H3K4 methyltransferase and Jhd2 H3K4 demethylase [ChIP-seq]
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic role in transcription and chromatin dynamics remains poorly understood. Here, we investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-15 | E-GEOD-81022 | biostudies-arrayexpress
TranscriptomicsGenes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm
In mature human sperm, genes of importance for embryo development (i.e. transcription factors) lack DNA methylation and bear nucleosomes with distinctive histone modifications, suggesting the specialized packaging of these developmental genes in the germline. Here, we explored the tractable zebrafis...
ORGANISM(S): Danio rerio 
2011-01-13 | E-GEOD-26609 | biostudies-arrayexpress
UnknownThe National Lung Screening Trial: overview and study design.
Not available
S-EPMC3009383 | biostudies-literature
TranscriptomicsCRISPR screen exploring resistance to AKTi (Capivasertib) in ER+ Breast Cancer in MCF7, T47D and CAMA-1 cell lines
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16438 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of DNA from two recently divergent mouse strains, 12925 and C57BL/6J
We have performed CGH analysis using 129S5 DNA competitively hybridised with C57BL/6J DNA to RPCI-23 (C57BL/6J) BAC clones spotted at 1Mb resolution (array protocol 7769)
ORGANISM(S): Mus musculus 
2005-04-01 | E-MEXP-298 | biostudies-arrayexpress
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