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MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
UnknownQuantification of tumour evolution and heterogeneity via Bayesian epiallele detection.
Not available
S-EPMC5526259 | biostudies-literature
TranscriptomicsInhibitor of NFκB ζ (IκBζ) is a transcriptional key regulator of monocyte chemoattractant protein-1 (MCP-1/CCL2)
Monocyte chemoattractant protein 1 (MCP-1/CCL2) is critically involved in directing the migration of blood monocytes to sites of inflammation. Consequently, excessive MCP-1 secretion has been linked to many (auto)inflammatory diseases, whereas a lack of expression severely impairs immune responsiven...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43075 | biostudies-arrayexpress
MetabolomicsIntracellular and extracellular metabolites from three strains of Prochlorococcus
Prochlorococcus is an abundant, cosmopolitan, marine cyanobacterium with ecotypes that vary temporally and spatially across oligotrophic regions of the global ocean. This group of organisms can serve as a model system to understand the accumulation of organic compounds synthesized by primary produce...
2018-10-23 | MTBLS567 | MetaboLights
MetabolomicsA Metabolomic Approach for Predicting Diurnal Changes in Cortisol

INTRODUCTION: The dysregulation of cortisol secretion has been associated with a number of mental health and mood disorders. However, diagnostics for mental health and mood disorders are behavioral and lack biological contexts.

OBJECTIVES: The goal of this ...

2021-09-23 | MTBLS1206 | MetaboLights
MetabolomicsIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids (GC- and LC-MS assays)

Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited...

2018-11-29 | MTBLS767 | MetaboLights
MetabolomicsHost-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Animals and their associated microbiota share long evolutionary histories. However, it is not always clear how host genotype and microbiota interact to affect phenotype. We applied a hologenomic approach to explore how host-microbiota interactions shape lifetime growth and parasite infection in f...

2024-01-24 | MTBLS8575 | MetaboLights
MetabolomicsIntracellular metabolites from an experimental manipulation of marine microorganisms
The marine environment holds one of the largest pools of reduced organic carbon on Earth. Within this organic carbon are metabolites produced as a result of microbial activity. This project considers the effects of predation and viral lysis on the metabolites found in the surface ocean. Using seawat...
2017-05-23 | MTBLS461 | MetaboLights
TranscriptomicsFlag Chromatin IP in Cyclin D1 Flag-HA tagged E.14.5 embryos versus Flag Chromatin IP in wildtype E.14.5 embryos
Cyclin D1 belongs to the core cell cycle machinery1, and it is frequently overexpressed in human cancers2. The full repertoire of cyclin D1 functions in normal development and in cancer cells is currently unknown. To address this question, here we introduce a novel approach that allows one to deter...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-13632 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cerebral cortex using two model strains (C57BL/6 and ApoE(-/-) on the C57BL background) upon episode hypoxia treatment
Study the gene expression variation at cerebral cortex using two mouse model strains (C57BL/6 and ApoE(-/-) on the C57BL background) upon episode hypoxia treatment
ORGANISM(S): Mus musculus 
2013-01-30 | E-TIGR-135 | biostudies-arrayexpress
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