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GenomicsChIP-seq of EGR1 in human primary unstimulated monocytes and in unstimulated human monocytes from three CMML patients
Identification of EGR1 chromatin localization in human primary monocytes (2 donors), in human primary monocytes from 2 CMML patients with TET2 truncating mutations (high VAF) and in human primary monocytes from 1 CMML patients with TET2 truncating mutations with low VAF.
ORGANISM(S): Homo sapiens 
2021-11-15 | E-MTAB-11132 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human dendritic cells after Poly(I:C)-based or PGE2-based maturation
Generation of human monocyte-derived DCs Peripheral blood mononuclear cells (PBMC) were isolated by Ficoll density centrifugation from buffy coats or whole blood of healthy donors and resuspended in serum-free medium (CellGro, CellGenix GmbH, Freiburg, Germany), supplemented with penicillin (50U/ml)...
ORGANISM(S): Homo sapiens 
2008-11-01 | E-MEXP-1230 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis and comparison of E15 and adult rat lateral ventricular choroid plexus epithelial cells.
Transcriptome analysis of lateral ventricular choroid plexus epithelial cells of embryonic day 15 (E15) and adult control Sprague-Dawley rats. We analyzed total RNA extracted from plexus epithelial cells from 6 pooled samples (3 E15, 3 adult) using the Illumina HiSeq 2000 platform.
ORGANISM(S): Rattus norvegicus 
2013-09-16 | E-GEOD-44072 | biostudies-arrayexpress
GenomicsAnalyses of Rad2, Mediator and RNA Polymerase II in different yeast mutant context.
We performed ChIP-seq analyses of Rad2, Mediator (Med17 and Med5) and RNA Polymerase II in Kin28-ts16 mutant, Med17-Q444P and Med17-Q444P/M442L mutants and in an Rpb9 deleted strain.
ORGANISM(S): Saccharomyces cerevisiae S288C 
2019-07-01 | E-MTAB-7081 | biostudies-arrayexpress
GenomicsChIP-seq of CSF-1R in THP-1 cell lines deleted for EGR1 gene by CRISPR-Cas9 and ChIP-seq of CSF-1R in 2 CMML patients
CSF-1R is recruited on EGR1 motifs in monocytes where it colocalizes with EGR1. To address if EGR1 required for CSF-1R recruitment on chromatin, THP-1 monocytic cell line has been deleted for EGR1 by CRISPR-Cas9 approach. 3 clones were generated by single cell cloning and CSF-1R localization on chro...
ORGANISM(S): Homo sapiens 
2019-03-28 | E-MTAB-7756 | biostudies-arrayexpress
GenomicsChIP-seq of CSF-1R, H3K4me1, H3K4me3 in human primary unstimulated monocytes and monocytes differentiated 72h with CSF-1 (3 healthy donors buffy coat) and in monocytes from two CMML patients and one healthy donor, EGR1 ChIP-seq in unstimulated monocytes (3 healthy donors buffy coat)
Identification of nuclear CSF-1R, H3K4me1 and H3K4me3 localization on chromatin in human primary monocytes and modification of this localization during monocyte differentiation into macrophage induced by 100ng/mL CSF-1 during 6 hours (1 donor) or 72h (3 donors). Identification of EGR1 chromatin loc...
ORGANISM(S): Homo sapiens 
2019-03-04 | E-MTAB-6305 | biostudies-arrayexpress
GenomicsChIP-Seq of H3K4me3 in primary unstimulated monocyte subsets from 2 healthy donors buffy coats
Identification of H3K4me3 localization on chromatin in primary unstimulated monocyte subsets
ORGANISM(S): Homo sapiens 
2018-11-09 | E-MTAB-7290 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms involved in adipose tissue-derived stromal cell hepatic conversion
Background: Adipose tissue-derived stromal cells (ATSCs) hold great promises in regenerative medicine, due to their easy retrieval, high proliferative capacity, and multi-lineage differentiation potential. In the last decade, several studies have reported the plasticity of ATSCs toward a hepatic fat...
ORGANISM(S): Homo sapiens 
2009-12-14 | E-GEOD-18201 | biostudies-arrayexpress
GenomicsChiP-seq of H3K4me3 in primary unstimulated monocytes from 3 healthy donors buffy coats and from 4 CMML patients
Identification of H3K4me3 localization on chromatin in primary unstimulated monocytes
ORGANISM(S): Homo sapiens 
2018-11-09 | E-MTAB-6689 | biostudies-arrayexpress
TranscriptomicsInhibition of extracellular vesicle-derived miR-146a-5p decreases the progression of melanoma brain metastasis in vitro and in vivo
Development of melanoma brain metastasis is caused by an interaction between tumor cells and normal cells in the brain microenvironment. miRNAs delivered by exosomes derived from the tumor cells seem to prime the brain microenvironment, prior to extravasation of tumor cells into the brain. We invest...
ORGANISM(S): Homo sapiens 
2023-09-29 | E-MTAB-11798 | biostudies-arrayexpress
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