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TranscriptomicsSex of Blood
Blood samples were taken at 1:00 pm +/- 1 h (Potassium-EDTA-monovettes, Sarstedt, Numbrecht, Germany) to control for circadian influences on gene expression. Blood was taken from normal male controls, normal female controls as well as different patients with disorders of sex development leading to a...
ORGANISM(S): Homo sapiens 
2009-07-13 | E-GEOD-11235 | biostudies-arrayexpress
TranscriptomicsWhole genome expression array profiling highlights differences in mucosal defense genes in Barrett's esophagus and esophageal adenocarcinoma.
Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett’s esophagus (BE), which is believed to form in response to ...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-28302 | biostudies-arrayexpress
MetabolomicsMining for natural product antileishmanials in a fungal extract library
Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the World’s poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes ...
2021-02-12 | MTBLS868 | MetaboLights
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
UnknownDNA repair gene XRCC1 polymorphisms and bladder cancer risk.
Not available
S-EPMC1865553 | biostudies-literature
UnknownRemdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.
Not available
S-EPMC7806502 | biostudies-literature
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
TranscriptomicsP15 Rat Sciatic Nerve ChIP-Chip with NuRD complex components
The NuRD complex is required for efficient and timely myelination in the peripheral nervous system. ChIP-chip assays were performed on rat sciatic nerve at P15, a peak timepoint of myelination, for binding of Chd4 to genes involved in regulating myelin formation. This experiment includes two custom...
ORGANISM(S): Rattus norvegicus 
2011-07-25 | E-GEOD-30890 | biostudies-arrayexpress
TranscriptomicsAntitumor Activity of (R,R’)-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse
(R,R’)-4-methoxy-1-naphthylfenoterol (MNF) inhibits in vitro proliferation of several types of cancer cell lines. In this study, the in vivo antitumor effects of MNF were evaluated using rat C6 glioma cells implanted subcutaneously into the lower flank of 5 week-old NMRI/Nude female Swiss mice. Thre...
ORGANISM(S): Rattus norvegicus 
2015-08-06 | E-GEOD-45307 | biostudies-arrayexpress
UnknownPronounced somatic bottleneck in mitochondrial DNA of human hair.
Not available
S-EPMC6939377 | biostudies-literature
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