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TranscriptomicsGene expression changes during retinal development and rod specification.
Photoreceptor disorders are collectively known as retinal degeneration (RD), and include retinitis pigmentosa (RP), cone-rod dystrophy and age related macular degeneration (AMD). These disorders are largely genetic in origin; individual mutations in any one of >200 genes cause RD, making mutation sp...
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-59201 | biostudies-arrayexpress
UnknownA role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice.
Not available
S-EPMC2570858 | biostudies-literature
TranscriptomicsRNA-seq of brown adipocyte mouse cells treated with different concentrations of DNA origami structures with organized insulin molecules or free insulin molecules against untreated controls
Insulin binds the insulin receptor (IR), which in turn has showed to form nanoclusters at the cell membrane. Trying to exploit the nanoscale spatial organization of IR, we developed rod-like insulin-DNA-origami nanostructures carrying different numbers of insulin molecules. These structures (referre...
ORGANISM(S): Mus musculus 
2023-07-03 | E-MTAB-12160 | biostudies-arrayexpress
TranscriptomicsComparison of the retinal transcriptomes of four Bhlhe23-/- mice and 4 sex and litter-matched wild type mice
Bhlhe23 is a transcription factor that is required for the maturation and survival of retinal rod bipolar cells in mice. In the adult Bhlhe23-/- retina, rod bipolar cells are almost completely absent. We identified genes that were likely to be important to rod bipolar cell maintenance and function ...
ORGANISM(S): Mus musculus 
2017-09-20 | E-MTAB-6069 | biostudies-arrayexpress
TranscriptomicsRNA-seq of retina from 6 pairs of litter-matched Bhlhe23-/- and wild type mice at postnatal day 7
Bhlhe23 is a transcription factor that is required for the maturation and survival of retinal rod bipolar cells in mice. In the Bhlhe23-/- retina, rod bipolar cells are born in normal numbers, then die by apoptosis from postnatal day 8. We identified genes that were likely to be important to rod bi...
ORGANISM(S): Mus musculus 
2017-09-20 | E-MTAB-6071 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas
We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which gene pathways were affected by Dicer loss, RNA sequencing was performed in whole neural retinas of P21 control and Dicer CKO mice. This...
ORGANISM(S): Mus musculus 
2019-01-14 | E-MTAB-6133 | biostudies-arrayexpress
TranscriptomicsmiRNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas
We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which miRNAs were involved in such phenotype, miRNA sequencing was performed in whole retinas of P21 and 3.5 month old control and Dicer CKO ...
ORGANISM(S): Mus musculus 
2019-01-14 | E-MTAB-6132 | biostudies-arrayexpress
TranscriptomicsComparison of wild-type and Mfsd2a KO eye cups
Eye photoreceptor membrane discs in outer rod segments are highly enriched in the visual pigment rhodopsin and the omega-3 fatty acid docosahexaenote (DHA). The eye acquires DHA from blood, but transporters for DHA uptake across the blood-retinal barrier (BRB) or retinal pigment epithelium have not ...
ORGANISM(S): Mus musculus 
2016-03-23 | E-GEOD-77403 | biostudies-arrayexpress
TranscriptomicsChromosome segregation in Streptococcus pneumoniae
Segregation of replicated chromosomes during cell division is an essential process in all organisms. Chromosome segregation is promoted by the action of the DNA-binding ParB protein in the rod-shaped model bacterium Bacillus subtilis. How oval shaped bacteria, such as the human pathogen Streptococcu...
ORGANISM(S): Streptococcus pneumoniae 
2011-06-11 | E-GEOD-26839 | biostudies-arrayexpress
TranscriptomicsUsing RNA Seq to define the regulon of the Pseudomonas aeruginosa transcription factor Anr in low-oxygen colony biofilms.
Purpose : The goal of this study was to use RNA Seq to define the regulon of the transciption factor Anr by comparing global transcriptional profiles of Pseudomonas aeruginosa strain PAO1 and a clinical isolate with their isogenic ?anr mutants, grown in colony biofilms at 1% oxygen. Methods : mRNA p...
ORGANISM(S): Pseudomonas aeruginosa 
2015-06-29 | E-GEOD-68534 | biostudies-arrayexpress
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