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GenomicsBeta arrestin1 associated genomic regions in nicotine induced Non-Small Cell Lung Carcinoma (NSCLC) cell line A549
The multifunctional scaffolding protein M-NM-2-arrestin-1 plays a vital role in mediating the proliferative effects of nicotine through nAChR signaling. M-NM-2-arrestins were initially known as negative regulators of GPCR mediated signaling as they promote internalization and desensitization of GPCR...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-40689 | biostudies-arrayexpress
GenomicsCell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3
The TCF7L2 transcription factor is linked to a variety of human diseases, including type 2 diabetes and cancer. One mechanism by which TCF7L2 could influence expression of genes involved in diverse diseases is by binding to distinct regulatory regions in different tissues. To test this hypothesis, ...
ORGANISM(S): Homo sapiens 
2012-06-05 | E-GEOD-38447 | biostudies-arrayexpress
GenomicsComparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions in 24 tumor and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potent...
ORGANISM(S): Homo sapiens 
2012-10-26 | E-GEOD-39068 | biostudies-arrayexpress
TranscriptomicsMouse-Monkey Time-series
Viral and bacterial infections of the lower respiratory tract are major causes of mortality and morbidity worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. In the study we examined the response of alveolar macropha...
ORGANISM(S): Macaca_fascicularis 
2011-08-02 | E-MTAB-427 | biostudies-arrayexpress
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