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TranscriptomicsDiet induced obesity is independent of metabolic endotoxemia, Tlr4 signalling and hypothalamic inflammation
A number of studies have proposed that excess food intake, particularly of high fat diets arise due dysregulation of homeostatic mechanisms regulating neuroendocrine control of appetite and energy balance. Current dogma suggests high fat diets invoke hypothalamic inflammation which reduces hypothala...
ORGANISM(S): Mus musculus 
2018-10-23 | E-MTAB-6929 | biostudies-arrayexpress
MetabolomicsMolecular investigation of Tuscan sweet cherries sampled over three years: gene expression analysis coupled to metabolomics and proteomics

Sweet cherry (Prunus avium L.) is a stone fruit widely consumed and appreciated for its organoleptic properties, as well as its nutraceutical potential. We here investigated the characteristics of six non-commercial Tuscan varieties of sweet cherry maintained at the Regional Germplasm Ba...

2021-10-29 | MTBLS1803 | MetaboLights
GenomicsCanonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation [ChIP-seq]
The histone 3 lysine 9 (H3K9)-specific methyltransferase (KMT) Setdb1 is essential for both stem cell pluripotency and terminal differentiation of different cell types. To shed light on Setdb1 role(s) in these mutually exclusive processes, we used mouse skeletal myoblasts as a model of terminal diff...
ORGANISM(S): Mus musculus 
2016-02-01 | E-GEOD-65493 | biostudies-arrayexpress
GenomicsIdentification of Elg1 interaction partners and effects on post-replication chromatin re-formation
Elg1, the major subunit of a Replication Factor C-like complex, is critical to ensure genomic stability during DNA replication, and is implicated in controlling chromatin structure. We investigated the consequences of Elg1 loss for the dynamics of chromatin re-formation following DNA replication. Me...
ORGANISM(S): Saccharomyces cerevisiae 
2018-10-31 | E-MTAB-6985 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of P. aeruginosa biofilms treated with tobramycin grown on CFBE41o- cells
We grew Pseudomonas aeruginosa biofilms on CFBE41o- human airway cells in culture, and we treated these biofilms with tobramycin. Microarray analysis was performed to gain an understanding of the global transcriptional changes that occur during antibiotic treatment. Experiment Overall Design: We co...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-18 | E-GEOD-9989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa treated with tobramycin
This SuperSeries is composed of the following subset Series:; GSE9989: Tobramycin Treatment of P. aeruginosa Biofilms Grown on CFBE41o- Cells; GSE9991: Tobramycin Treatment of Planktonic Pseudomonas aeruginosa Experiment Overall Design: Refer to individual Series
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-18 | E-GEOD-10030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin fibroblasts treated with ascorbic acid
Effect of Ascorbic acid on human genome
ORGANISM(S): Homo sapiens 
2009-10-15 | E-MEXP-1861 | biostudies-arrayexpress
UnknownImpact of poverty and adversity on perceived family support in adolescence: findings from the UK Millennium Cohort Study.
Not available
S-EPMC11424735 | biostudies-literature
GenomicsSWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes
Genome-wide binding of the histone chaperone Rtt106 was analysed by ChIP-seq. Rtt106 binding was analysed in WT and the mutant backgrounds lacking transcription factors Pdr1 and Pdr3, the HIR histone chaperone subunit Hir1, or the boundary protein Yta7. Two biological replicates had been submitted. ...
ORGANISM(S): Saccharomyces cerevisiae 
2022-02-21 | E-MTAB-9787 | biostudies-arrayexpress
TranscriptomicsLongitudinal scRNAseq profiling of memory B cells in severe COVID19 patients
Memory B cells play a fundamental role in host defences against viruses. This dataset aimed at understanding their maturation and stability in the context of SARS-CoV-2 infection and consist of a longitudinal single-cell and repertoire profiling of the B cell response up to six months in four severe...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9995 | biostudies-arrayexpress
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