Sort   by:  
 Page size 
MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
ProteomicsEvaluation of Therapeutic Potential of Resveratrol-Loaded Nanostructured Lipid Carriers on Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Patients Fibroblasts
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurological disease characterized by autosomal recessive mutations in the sacsin gene (SACS), that cause in patients progressive cerebellar atrophy, damage of the peripheral nerves, and significant retinal changes and cognitive...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025718 | Pride
Nanostructured lipid carriers Arsacs Oxidative stress Resveratrol 
ProteomicsPROTEOMIC ANALYSIS OF URINARY EXTRACELLULAR VESICLES OF KIDNEY TRANSPLANT RECIPIENTS WITH BKV VIRURIA AND VIREMIA.
Background: Although the clinical fingerprints of the BK virus (BKV) infection in kidney transplant recipients (KTRs) has been well documented, the systemic biological machinery involved in this complication is still poorly recognized. Proteomics analysis of urinary extracellular vesicles (EVs) can ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD035494 | Pride
Proteomics Mass spectrometry Urinary extracellular vesicles Bk virus Kidney transplant recipients 
ProteomicsProteomic Profiling of Cerebrospinal Fluid and its EVs from Extraventricular Drainage in Pediatric Pilocytic Astrocytoma, Towards Precision Oncology
Pediatric pilocytic astrocytoma (PA) is the most common brain tumor in children. Complete resection provides a good prognosis, except for unresectable PA forms. There is an incomplete understanding of the molecular and cellular pathogenesis of PA. Potential biomarkers for PA patients, especially the...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD050589 | Pride
Cerebrospinal fluid  extraventricular drainage  extracellular vesicles  exosome  microvesicle  proteomics  pilocytic astrocytoma 
ProteomicsIn vitro pilot study of polydopamine nanoparticles as protective antioxidant agents on fibroblasts cells derived from ARSACS patients
Reactive oxygen species (ROS) are active molecules involved in several biological functions. When the production of ROS is not counterbalanced by the action of protective antioxidant mechanisms present in living organisms, a condition of oxidative stress can arise with consequent damage to biologica...
ORGANISM(S): Homo sapiens (Human) 
2022-06-22 | PXD032916 | Pride
Reactive oxygen species Arsacs Polydopamine nanoparticles Fibroblasts 
ProteomicsPlasma-derived exosome proteins as novel diagnostic and prognostic biomarkers in neuroblastoma patients
Neuroblastoma (NB) is the most common extracranial solid tumor during infancy, causing up to 10% of mortality in children. NB shows notable heterogeneity with regard to histology and clinical behavior, ranging from low-risk localized tumors (LR-NB) to high-risk disease (HR-NB), characterized by aggr...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042422 | Pride
Exosomes Proteomics Mass spectrometry Extracellular vesicles Neuroblastoma 
ProteomicsPROTEOMIC PROFILING OF AMNIOS FOR PRETERM BIRTH BIOMARKER DISCOVERY
Spontaneous preterm birth (PTB) complicates about 12% of pregnancies worldwide, remaining the main cause of neonatal morbidity and mortality. A consistent number of PTB are caused by microbial-induced preterm labor, mediated by an inflammatory process, that threatens both maternal and newborn health...
ORGANISM(S): Homo sapiens (Human) 
2021-12-06 | PXD028343 | Pride
Proteomics Inflammation Amnios Mass spectrometry Preterm birth Biomarker 
ProteomicsArtificial Intelligence in proteomic profiling of Cerebrospinal fluid from extraventricular drainage in child Medulloblastoma
Medulloblastoma (MB) is the most common pediatric malignant central nervous system tumor. Overall survival in MB depends on treatment tuning. There is the need for biomarkers of residual disease, and recurrence. We analysed the proteome of waste cerebrospinal fluid (CSF) from extraventricular draina...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035292 | Pride
Cerebrospinal fluid Central nervous system Mass spectrometry Proteomics Medulloblastoma 
ProteomicsCombining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid nanocarriers during blood-brain barrier crossing
Upon entering in contact with the biological environment, nanostructures are immediately covered by biomolecules, and in particular proteins forming the so-called “protein corona” (PC). The phenomenon of PC formation has gained great attention in recent years due to its implication for the use of na...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031034 | Pride
Protein corona  blood-brain barrier  lipid nanoparticles  magnetic nanoparticles  super resolution microscopy  dstorm  mass spectroscopy. 
ProteomicsHybrid Epithelial-Mesenchymal status of lung cancer dictates metastatic success through differential interaction with NK cells
Background Epithelial to mesenchymal transition (EMT) endows cancer cells with pro-metastatic properties, which appear most effective when cells enter an intermediate hybrid (H) state, characterized by integrated mesenchymal (M) and epithelial (E) traits. The reasons for this advantage are poorly kn...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044297 | Pride
Cancer initiating cell Proteomics Mass spectrometry Natural killer Epithelial-to-mesenchymal transition 
Sort   by:  
 Page size