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GenomicsNitrogen regulatory protein C couples nitrogen stress response and stringent response in nitrogen starved Escherichia coli.
We show that NtrC couples the Ntr stress response and stringent response in N starved E. coli, which appears to be a conserved adaptive strategy employed by many bacteria to manage conditions of nutritional adversity. N starved Escherichia coli initiate the nitrogen regulation (Ntr) stress response ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-05-01 | E-MTAB-2211 | biostudies-arrayexpress
TranscriptomicsNitrogen stress response and stringent response are coupled in Escherichia coli
Assimilation of nitrogen is an essential process in bacteria. The nitrogen regulation stress response is an adaptive mechanism used by nitrogen-starved Escherichia coli to scavenge for alternative nitrogen sources and requires the global transcriptional regulator NtrC.
ORGANISM(S): Escherichia coli K-12 
2014-06-17 | E-MTAB-2612 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of growth on methanol in a typical fed batch culture of Pichia pastoris
We have followed a typical fed-batch induction regime for heterologous protein production under the control of the AOX1 promoter using both microarray and metabolomic analysis. The genetic constructs involved 1 and 3 copies of the TRY1 gene, encoding human trypsinogen, In small-scale laboratory cult...
ORGANISM(S): Pichia pastoris 
2014-10-01 | E-MTAB-2530 | biostudies-arrayexpress
TranscriptomicsInsights into the prevalence and underlying causes of clonal variation through transcriptomic analysis in Pichia pastoris
Clonal variation, wherein a range of specific productivities of secreted proteins are observed from supposedly identical transformants, is an ingrained aspect of working with Pichia pastoris. It means that a significant number of transformants need to be tested to obtain a representative sample, and...
ORGANISM(S): Komagataella pastoris 
2017-05-26 | E-MTAB-5124 | biostudies-arrayexpress
GenomicsDeciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress
The aim of this study was to extend our analysis to the obligate human pathogen M. tuberculosis, which has to deal with a more restricted set of environmental variables in terms of nitrogen sources, and to delineate the GlnR regulon, by peforming global analysis of GlnR-DNA interactions by Chromatin...
ORGANISM(S): Mycobacterium tuberculosis 
2014-12-01 | E-MTAB-2492 | biostudies-arrayexpress
TranscriptomicsGenome wide screen of estrogen receptor α regulated microRNAs reveals a negative autoregulatory feedback loop
Estrogen receptor alpha (ERα) is a nuclear receptor linked to progression of the majority of human breast cancers. Following activation ERα regulates the transcription of target genes via DNA binding. Through a genome wide approach we have identified a subset of microRNAs (miRNAs or miRs) modulate...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14685 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput of Blumeria gramis during infection of Barley
The aim of this experiment was to investigate the transcriptomic variation within Blumeria graminis f. sp. hordei during infection of Barley. SOLiD RNA-seq data was generated for 6 samples, three from the epiphytic hyphae and three from the haustoria within the epidermis.
ORGANISM(S): Blumeria graminis 
2012-06-11 | E-MTAB-682 | biostudies-arrayexpress
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