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ProteomicsInterferon Regulatory Factors: IRF1 and IRF7 directly regulate gene expression in bats in response to viral infection.
Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with IFNα signalling. Here we show IRF1,3 and 7 levels are elevated in most bat tissues and that basally, IRFs contribute to the expression of type I IFN ligands and high expression of Interferon Regula...
ORGANISM(S): Cellular Organisms 
2020-10-23 | PXD021982 | JPOST Repository
UnknownRespiratory bioenergetics is enhanced in human, but not bovine macrophages after exposure to <i>M. bovis</i> PPD: Exploratory insights into overall similar Cellular Metabolic Profiles.
Not available
S-EPMC11577332 | biostudies-literature
UnknownCalcium channel CNGC19 mediates basal defense signaling to regulate colonization by Piriformospora indica in Arabidopsis roots.
Not available
S-EPMC7210775 | biostudies-literature
TranscriptomicsTranscription profiling of EDS1- and SA-dependent genes in nudt7-1
nudt7-1 mutant plant exhibit stunted growth, enhanced basal resistance, elevated SA levels and spontaneous leaf cell death that is restricted to single cells but does not spread. All of these phenotypes depend on EDS1, a key regulator of plant innate immunity. Moreover, SA depletion in nudt7-1 resul...
ORGANISM(S): Arabidopsis thaliana 
2010-02-08 | E-MEXP-2405 | biostudies-arrayexpress
TranscriptomicsRNA-seq of RBC depleted whole blood from COVID-19 patients and controls
Red blood cells (RBC) depleted whole blood from COVID-19 patients and controls was harvested and processed in order to performed 10X single cell RNA-seq. For COVID-19 patients 2 samples 10 days a part were analyzed.
ORGANISM(S): Homo sapiens 
2020-08-21 | E-MTAB-9221 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling analysis of bacterial challenged Lateolabrax japonicus reveals deep insight into the immune-relevant genes in marine fish (RNA-seq)
We report the application of Solexa/IlluminaM-bM-^@M-^Ys RNA-seq sequencing approaches for transcriptome in a marine fish under different conditions (bacterial- and mock-challenged conditions). By obtaining over four billion bases of sequence from the cDNA, we generated 169,950 none-redundant consen...
ORGANISM(S): Lateolabrax japonicus 
2012-08-09 | E-GEOD-21721 | biostudies-arrayexpress
ProteomicsLabel-free quantification of proteins in wild type and CLPP-null mouse embryonic fibroblasts
We studied consequences of genetic deletion of mitochondrial peptidase CLPP for global proteome profile in unstressed cells.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023677 | Pride
Mitochondrial accumulation of ribosomes and nucleoids Basal innate immunity elevation Vdac-dependent release Antiviral state Lc-msms Cgas-sting-irf7-ifnb-stat1 activation 
TranscriptomicsCortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation [adults]
Chronic early life stress increases adult susceptibility to numerous health problems linked to chronic inflammation. One way that this may occur is via glucocorticoid-induced developmental programming. To gain insight into such programming, we treated zebrafish embryos with cortisol and examined the...
ORGANISM(S): Danio rerio 
2016-06-01 | E-GEOD-80260 | biostudies-arrayexpress
TranscriptomicsLung-resident myeloid-derived suppressor cells display dual functionality in experimental tuberculosis
Using cell-based approaches and experimental mouse models for pulmonary TB we unveiled MDSCs as new myeloid populations directly interacting with Mycobacterium tuberculosis (Mtb). MDSCs readily phagocytosed Mtb, released proinflammatory (IL-6, IL-1M-NM-1) and immunomodulatory (IL-10) cytokines while...
ORGANISM(S): Mus musculus 
2014-12-21 | E-GEOD-57124 | biostudies-arrayexpress
TranscriptomicsDiabetes and hypertension then reversal in a rat model of diabetic nephropathy
Fisher male Cyp1a1mRen2 rats were allocated into three groups of four or eight biological replicates each: control; combined induced diabetes and hypertension; removal of combined treatments. Kidneys were harvested for gene expression microarray analysis on Affymetrix GeneChip Rat Genome 230 2.0 Gen...
ORGANISM(S): Rattus norvegicus 
2013-04-10 | E-MEXP-3739 | biostudies-arrayexpress
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