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ProteomicsProteomics analysis reveals a role for E. coli polyphosphate kinase in regulation of membrane structure and polymyxin resistance via the BasS-BasR two component system
Polyphosphates (polyP) are chains of inorganic phosphates that can reach 1000s of residues in length. In Escherichia coli, polyP is produced by the polyP kinase (PPK) and is thought to play a protective role during the response to cellular stress. However, the pathways impacted by PPK activity and p...
ORGANISM(S): Escherichia coli 
2024-02-14 | PXD043566 | Pride
Lc-msms Cell culture Bacteria Label-free quantification E. coli 
TranscriptomicsNutritional programming of lifespan: Excessive sugar consumption in early adulthood curtails Drosophila survival by inhibiting dFOXO
Fruit flies were maintained either 40% sugar or 5% sugar diets for one week, then on 5% sugar for one further week. Whole flies were sampled at the end of weeks 1 and week 2. Persistent effects of past high sugar diets are identified.
ORGANISM(S): Drosophila melanogaster 
2017-01-11 | E-MTAB-4766 | biostudies-arrayexpress
TranscriptomicsSOX15 governs a transcriptional program in human esophageal stratified epithelium and in a subset of esophageal adenocarcinomas
We identified spatially restricted transcription factors and found SOX15 expression confined to stratified esophageal epithelium, with attenuation in Barrett's esophagus. SOX15 binds esophagus-specific loci and its loss in human esophageal cells affected esophagus-specific transcripts [RNA-Seq] Tota...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-62909 | biostudies-arrayexpress
TranscriptomicsAffymetrix 250K StyI SNP array data for gastric and esophageal adenocarcinoma cancer types
Using data from high-density genomic profiling arrays, we describe the profiles of somatic copy-number aberrations (SCNAs) in 486 adenocarcinomas across all three major digestive organs, including 296 gastric and esophageal cancers. This analysis revealed that although patterns of broad, chromosome ...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-36459 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP 6.0 array data for colon, gastric and esophageal adenocarcinoma cancer types
Using data from high-density genomic profiling arrays, we describe the profiles of somatic copy-number aberrations (SCNAs) in 486 adenocarcinomas across all three major digestive organs, including 296 gastric and esophageal cancers. This analysis revealed that although patterns of broad, chromosome ...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-36458 | biostudies-arrayexpress
TranscriptomicsGastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis.
This SuperSeries is composed of the following subset Series: GSE36458: Affymetrix SNP 6.0 array data for colon, gastric and esophageal adenocarcinoma cancer types GSE36459: Affymetrix 250K StyI SNP array data for gastric and esophageal adenocarcinoma cancer types Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-08-31 | E-GEOD-36460 | biostudies-arrayexpress
GenomicsMutant p53 regulates survivin to foster lung metastasis
Mutant p53 regulates survivin to foster lung metastasis
PRJNA601320 | ENA
UnknownProteomics analysis reveals a role for E. coli polyphosphate kinase in membrane structure and polymyxin resistance during starvation.
Not available
S-EPMC10350021 | biostudies-literature
GenomicExome Sequencing of Esophageal Adenocarcinoma

The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years. When coupled to the five-year survival rate of only 15% for this disease, identification of new therapeutic targets for EAC is of great importance. Here, we analyze the mutational spectra identified from the w...

phs000598 | dbGaP
GenomicGenomic Sequencing of Colorectal Adenocarcinomas

This study was the first-known effort to complete the complete genome sequencing of primary colorectal adenocarcinomas and the matched germline genome. Nine colorectal adenocarcinomas selected on the basis of having chromosomal instability were subjected to 'shotgun' Illumina sequencing w...

phs000374 | dbGaP
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