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TranscriptomicsModulation of mucosal immune responses to Clostridium difficile by peroxisome proliferator-activated receptor γ and microRNA-146b
BACKGROUND: miRNA have been shown to play an important role during immune-mediated diseases such as inflammatory bowel disease. The aim of this study was to assess differential expression of miRNA between uninfected and infected mice with Clostridium difficile strain VPI 10463 RESULTS: MicroRNA (miR...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-39235 | biostudies-arrayexpress
TranscriptomicsImmunoregulatory actions of T cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20523 | biostudies-arrayexpress
TranscriptomicsThe immunoregulatory effect of macrophage-specific PPAR gamma deficiency on experimental inflammatory bowel disease
Inflammatory bowel disease (IBD) is a condition characterized by severe intestinal inflammation and immune cell activation. The severity of the disease can be mitigated by compounds which activate peroxisome proliferator-activated receptor gamma (PPAR gamma), a receptor present widely in tissues in...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-23421 | biostudies-arrayexpress
TranscriptomicsImmunoregulatory actions of epithelial cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20621 | biostudies-arrayexpress
ModelsLeber2015 - Mucosal immunity and gut microbiome interaction during C. difficile infection
Leber2015 - Mucosal immunity and gut microbiome interaction during C. difficile infection This model is described in the article: Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection. Leber A, Viladomiu M, Hont...
2024-09-02 | BIOMD0000000583 | BioModels
ModelsLeber2016 - Expanded model of Tfh-Tfr differentiation - Helicobacter pylori infection
Leber2016 - Expanded model of Tfh-Tfr differentiation - Helicobacter pylori infection The parameters used in the model were obtained from experiments conducted by the authors, previous publications [ 1, 2, 3] and parameter optimisation carried out in the paper using particle swarm and geneti...
2024-09-02 | BIOMD0000000625 | BioModels
ModelsCarbo2013 - Cytokine driven CD4+ T Cell differentiation and phenotype plasticity
Carbo2013 - Cytokine driven CD4+ T Cell differentiation and phenotype plasticity CD4+ T cells can differentiate into different phenotypes depending on the cytokine milieu. Here a computational and mathematical model with sixty ordinary differential equations representing a CD4+ T ...
2024-09-02 | BIOMD0000000451 | BioModels
ModelsBaker(2022) - Immunometabolic Model
Novel computational modeling of bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions ABSTRACT We built a novel computational model of complex mechanisms at the intersection of immunity and metabolism that regulate CD4+ T cell effector and regulatory functions by usin...
2022-12-02 | MODEL2211070001 | BioModels
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