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ProteomicsHuman CSF peptidomics of gamma secretase inhibition
Fifteen human healthy volunteers, divided into three groups, received a single dose of placebo or either 140 mg or 280 mg of the ?-secretase inhibitor semagacestat (LY450139). Endogenous peptides in CSF, sampled prior to administration of the drug and at six subsequent time points, were analyzed by ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080870 | MassIVE
ProteomicsAlzheimer's Disease Isomerization
Amino acid isomerization is a spontaneous chemical modification potentially related to the underlying causes of Alzheimer’s disease (AD). We demonstrate that data-independent acquisition mass spectrometry can be used to characterize isomerization in complex protein mixtures. Examination of a large c...
ORGANISM(S): Homo Sapiens 
2022-03-16 | PXD025668 | panorama
ProteomicsA Peptide-Centric Quantitative Proteomics Dataset for the Phenotypic Assessment of Alzheimer’s Disease
Alzheimer’s disease (AD) is a looming public health disaster with limited interventions. Desperately needed progress in therapeutic development rests on more detailed understanding of molecular pathogenesis. The vast majority of existing data for AD pathogenesis in humans is from standard neuropatho...
ORGANISM(S): Homo Sapiens 
2023-04-18 | PXD034525 | panorama
UnknownDevelopment of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.
Not available
S-EPMC10214179 | biostudies-literature
UnknownMultimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study.
Not available
S-EPMC9988262 | biostudies-literature
UnknownDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Not available
S-EPMC11408082 | biostudies-literature
UnknownMeasurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study.
Not available
S-EPMC11578795 | biostudies-literature
UnknownEffect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC8491132 | biostudies-literature
UnknownOlfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort.
Not available
S-EPMC12464792 | biostudies-literature
UnknownSex Differences in Long COVID.
Not available
S-EPMC11755195 | biostudies-literature
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