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TranscriptomicsEffect of 5-azacytidine on gene expression in C2C12 myoblasts
Mesenchymal progenitor cells can be differentiated in vitro into myotubes that exhibit many characteristic features of primary mammalian skeletal muscle fibers. However, in general, they do not show the functional excitation-contraction coupling or the striated sarcomere arrangement typical of matur...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-30192 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of muscle and liver tissue in collagen-induced arthritis (CIA) and control mice treated with increasing doses of prednisolone
Prednisolone is a potent anti-inflammatory glucocorticoid (GC) but chronic use is hampered by metabolic side effects. Although GCs are predominantly prescribed for treatment of inflammatory conditions, little is known about their long-term effects on gene-expression in-vivo during inflammation. Here...
ORGANISM(S): Mus musculus 
2013-11-10 | E-MTAB-1765 | biostudies-arrayexpress
TranscriptomicsProfiling of Jurkat T cells activated with CD3, CD28 and PMA and multiple kinase inhibitors
T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into the Th1, Th2, Th17 or iTreg phenotype, depending on environmental co-stimulatory signals. In order to identify the genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes ...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30674 | biostudies-arrayexpress
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