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ProteomicsChanges in muscle size rewires glucose metabolism in mice
Research, especially on cancer, shows that growing cells reprogram their metabolism and synthesise lactate even in the presence of oxygen. This phenomenon has been termed the Warburg effect, and one of its key functions is to generate glycolytic intermediates for anabolic reactions to support the ge...
ORGANISM(S): Mus Sp. (ncbitaxon:10095) 
2022-12-08 | MSV000090865 | MassIVE
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
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