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The most virulent human malaria parasite, Plasmodium falciparum, has a complex life cycle between its human host and mosquito vector. Each stage is driven by a specific transcriptional program, but with a relatively high ratio of genes to specific transcription factors, it is unclear how genes are a...
ORGANISM(S): Homo sapiens (Human) 
2023-10-04 | PXD035225 | Pride
Malaria parasites have evolved a well-adjusted developmental program to progress through the complex life cycle in the human and mosquito host. Here we identify cytosine methylation of tRNAAsp (GTC) as being critical to maintain stable protein synthesis under cellular stress. Using conditional knock...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-02-13 | PXD024769 | Pride
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