AML is a prevalent hematologic neoplasms disease. Around 13% AML patients harbor somatic mutations in cohesin complex genes. We performed IP-MS and detected SMC3-interacting proteins in OCI-AML3 cells.
DNA Double-Strand Breaks (DSBs) are highly detrimental since they can lead to mutations and chromosomes rearrangements (amplification, deletion, translocation and chromosome loss). ChIP-chip of P-SMC3 (S1083) and P-SMC1 (S966) were used to show the recruitment of these marks on DNA repair foci. ChIP...
The most virulent human malaria parasite, Plasmodium falciparum, has a complex life cycle between its human host and mosquito vector. Each stage is driven by a specific transcriptional program, but with a relatively high ratio of genes to specific transcription factors, it is unclear how genes are a...
In this study, we employed the photoactivatable crosslinker (sulfo-SDA) to investigate protein-protein interaction between human Separase-Scc1 fusion protein and SMC1/SMC3 cohesin subunits complex in the presence of DNA.
