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ProteomicsFission yeast Caprin protein is required for efficient heterochromatin establishment.
Heterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving histone methylation and non-coding RNAs. However,...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-02-14 | PXD050937 | Pride
Caprin Shotgun proteomics Schizosaccharomyces pombe Rna Heterochromatin Label-free quantitation 
ProteomicsSUMOylation regulates Lem2 function in centromere clustering and silencing.
Regulation by the small modifier SUMO is heavily dependent on spatial control of enzymes that mediate the attachment and removal of SUMO on substrate proteins. Here we show that in fission yeast, delocalisation of the SUMO protease Ulp1 from the nuclear envelope results in centromeric defects that c...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-11-20 | PXD046003 | Pride
Ubiquitination Centromere Lem2 Sumoylation Fission yeast 
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