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ProteomicsSUMOylation regulates Lem2 function in centromere clustering and silencing.
Regulation by the small modifier SUMO is heavily dependent on spatial control of enzymes that mediate the attachment and removal of SUMO on substrate proteins. Here we show that in fission yeast, delocalisation of the SUMO protease Ulp1 from the nuclear envelope results in centromeric defects that c...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-11-20 | PXD046003 | Pride
Ubiquitination Centromere Lem2 Sumoylation Fission yeast 
ProteomicsLEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
Quantitative crosslinking analysis to probe in vitro conformational dynamics governing ESCRT-mediated nuclear envelope formation. CHMP7 was crosslinked with D12-BS3 while CHMP7 in the presence of LEM2 winged helix domain was crosslinked with H12-BS3. Samples were mixed after crosslinking and analy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-24 | MSV000084837 | MassIVE
GenomicsLem2 is essential for cardiac development by maintaining nuclear integrity
Lem2 is essential for cardiac development by maintaining nuclear integrity
PRJNA900158 | ENA
GenomicsRNA surveillance and the periphery: a novel role for nuclear envelope protein Lem2
RNA surveillance and the periphery: a novel role for nuclear envelope protein Lem2
PRJNA729495 | ENA
TranscriptomicsRNA surveillance and the periphery: a novel role for nuclear envelope protein Lem2 
Transcriptionally silent chromatin often localizes at the nuclear periphery, but whether post-transcriptional gene repression also occurs at the nuclear envelope (NE) remains unknown. Here we demonstrate that the NE protein Lem2 cooperates with the nuclear exosome in RNA degradation. Loss of Lem2 ca...
ORGANISM(S): Schizosaccharomyces pombe 
2021-05-31 | GSE174347 | GEO
UnknownComparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair.
Not available
S-EPMC7072835 | biostudies-literature
UnknownLEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation.
Not available
S-EPMC7321842 | biostudies-literature
UnknownLem2 is essential for cardiac development by maintaining nuclear integrity.
Not available
S-EPMC10478753 | biostudies-literature
UnknownSUMOylation regulates Lem2 function in centromere clustering and silencing.
Not available
S-EPMC10730020 | biostudies-literature
UnknownThe inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery.
Not available
S-EPMC9507967 | biostudies-literature
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