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GenomicsSequences Associated with Centromere Competency in the Human Genome
Centromeres, the sites of spindle attachment during mitosis and meiosis, are located in specific positions in the human genome, normally coincident with diverse subsets of alpha satellite DNA. While there is strong evidence supporting the association of some subfamilies of alpha satellite with centr...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-45497 | biostudies-arrayexpress
GenomicsCentromere-Like Regions in Budding Yeast
Accurate chromosome segregation requires centromeres (CENs), the chromosomal sites where kinetochores form, to bridge DNA and attach to microtubules. In contrast to most eukaryotes, Saccharomyces cerevisiae possesses sequence-defined point centromeres. Chromatin immunoprecipitation followed by seq...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-18 | E-GEOD-31466 | biostudies-arrayexpress
GenomicsSequential centromere shift via de novo formation in maize
The ability of centromeres to alternate between active and inactive states indicates significant epigenetic elements controlling centromere assembly and centromere function. In maize (Zea mays), misdivision of the B chromosome centromere on a translocation with the short arm of chromosome 9 (TB-9Sb)...
ORGANISM(S): Zea mays 
2015-03-03 | E-GEOD-59124 | biostudies-arrayexpress
GenomicsComposition and organization of active centromere sequences in complex genomes
We report the sequences bound to CENP-A in the dog genome (Canis familiaris) for high-throughput characterization of centromeric sequences. We compare these ChIPSeq reads (72 bp, single read) against a reference centromeric satellite DNA domain database for the dog genome, resulting in the annotatio...
ORGANISM(S): Canis lupus familiaris 
2012-07-23 | E-GEOD-38079 | biostudies-arrayexpress
TranscriptomicsDisplacement and re-accumulation of centromeric cohesin during transient pre-anaphase centromere splitting
The ring-shaped cohesin complex links sister chromatids until their timely segregation during mitosis. Cohesin is enriched at centromeres, where it provides the cohesive counter-force to bi-polar tension produced by the mitotic spindle. As a consequence of spindle tension, centromeric sequences tran...
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-29 | E-GEOD-8661 | biostudies-arrayexpress
TranscriptomicsGenomic and genetic characterization of rice Cen3 reveals evolutionary remnants of a complex centromere (mRNA data)
The centromere is the chromosomal site for assembly of the kinetochore where spindle fibers attach during cell division. In most muticellular eukaryotes, centromeres are composed of long tracks of satellite repeats that are recalcitrant to sequencing and fine scale genetic mapping. Here we report ...
ORGANISM(S): Oryza sativa 
2006-05-26 | E-GEOD-4920 | biostudies-arrayexpress
TranscriptomicsMyb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast
The TTAGGG motif is common to two seemingly unrelated dimensions of chromatin function M-^V the vertebrate telomere repeat and the promoter regions of many Schizosaccharomyces pombe genes, including all of those encoding canonical histones. The essential S. pombe protein Teb1 contains two Myb-like D...
ORGANISM(S): Schizosaccharomyces pombe 
2013-08-14 | E-MTAB-1253 | biostudies-arrayexpress
TranscriptomicsGenomic and genetic characterization of rice Cen3 reveals evolutionary remnants of a complex centromere (small RNA data)
The centromere is the chromosomal site for assembly of the kinetochore where spindle fibers attach during cell division. In most muticellular eukaryotes, centromeres are composed of long tracks of satellite repeats that are recalcitrant to sequencing and fine scale genetic mapping. Here we report ...
ORGANISM(S): Oryza sativa 
2006-05-26 | E-GEOD-4912 | biostudies-arrayexpress
GenomicsRole of Fun30 in chromatin remodelling and centromere function
To investigate the role of Fun30 in centromere establishment and function
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-27 | E-MTAB-759 | biostudies-arrayexpress
TranscriptomicsSpo11-oligo mapping in S. cerevisiae Ctf19/CCAN kinetochore sub-complex mutant mcm21
During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in huma...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-15 | E-GEOD-72683 | biostudies-arrayexpress
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