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ProteomicsIdentification of BBOX1 binding partners using AP-MS in ccRCC tumors
Gamma-Butyrobetaine Hydroxylase 1 (BBOX1) is a 2-OG dependent enzyme evolving in carnitine synthesis and lipid metabolism. In this study, we propose BBOX1 is a potential tumor suppressor in kidney cancer. We found that BBOX1 is generally underexpressed in ccRCC cells and patients. Restore BBOX1 in c...
ORGANISM(S): Homo sapiens (Human) 
2024-12-23 | PXD050455 | Pride
Bbox1 Ccrcc 
TranscriptomicsBBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is a metabolic disease that is believed to arise from renal proximal convoluted tubule (PCT) epithelial cells. However, the signaling events leading to ccRCC development are not completely understood. Here, we report that a carnitine synthesis enzyme predomina...
ORGANISM(S): Homo sapiens 
2024-12-23 | GSE261401 | GEO
GenomicsBBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma
BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma
PRJNA1086871 | ENA
GenomicsIdentification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer
Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer
PRJNA638951 | ENA
TranscriptomicsIdentification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease. Because of its heterogeneity and lack of hormone receptors or HER2 expression, targeted therapy is limited. Here, by performing a functional siRNA screening for 2-OG–dependent enzymes, we identified gamma-butyrobetaine ...
ORGANISM(S): Homo sapiens 
2020-12-02 | GSE152317 | GEO
UnknownXLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding.
Not available
S-EPMC4162623 | biostudies-literature
UnknownIdentification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.
Not available
S-EPMC7642036 | biostudies-literature
UnknownBBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma.
Not available
S-EPMC11814379 | biostudies-literature
UnknownBBOX1-AS1 Accelerates Nasopharyngeal Carcinoma Progression by Sponging miR-3940-3p and Enhancing KPNA2 Upregulation.
Not available
S-EPMC8687136 | biostudies-literature
UnknownBiallelic variants in BBOX1 cause L-Carnitine deficiency and elevated γ-butyrobetaine.
Not available
S-EPMC12480863 | biostudies-literature
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