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MetabolomicsMetabolomics of human primary B-ALL cells treated by BCR-Abl1 inhibitor, STI571, and p190 BCR-Abl+ BAF3 cells with ASS1 knockdown
Analyze the Metabolomics changes in B-ALL cells after the treatment of imatinib and p190+ BAF3 cells with ASS1 knockdown or left untreated. two methods as the below LC-MS description showed were used.
2026-07-08 | MTBLS14638 | MetaboLights
TranscriptomicsGene expression profiling in BCR-ABL expressing LSCs and BCR-ABL-BLK expressing LSCs
Using BCR-ABL-induced chronic myeloid leukemia (CML) as a disease model for leukemia stem cells (LSCs), we showed that BCR-ABL down-regulates the B lymphoid kinase (Blk) gene in leukemia stem cells in CML mice and that Blk functions as a tumor suppressor in LSCs and suppresses LSC function. Inhibiti...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-36096 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Alox5-/-LSCs
We previously demonstrated that Alox5 deficiency impairs the function of LSCs and prevents the initiation of BCR-ABL-induced CML. To identify the pathways in which Alox5 gene regulates function of LSCs, we performed a comparative DNA microarray analysis using total RNA isolated from non-BCR-ABL-expr...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29347 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses
The profiles of transcripts of Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses were compared using microarrays to investigate
ORGANISM(S): Homo sapiens 
2007-10-31 | E-TABM-173 | biostudies-arrayexpress
TranscriptomicsRegulation of hTERT by BCR-ABL at multiple levels in K562 cells
To investigate the mechanism of telomerase regulation in BCR-ABL positive cells due to its clinical value, we studied the catalytic component of telomerase, TERT. Our results suggest that BCR-ABL plays an important role in regulating hTERT in K562 (BCR-ABL positive human leukemia) cells. When Gleeve...
ORGANISM(S): Homo sapiens 
2011-12-15 | E-GEOD-26821 | biostudies-arrayexpress
TranscriptomicsWnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl
Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to completely eradicate Bcr-Abl+ leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl+ leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-ba...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-21499 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BCR-ABL positive and negative adult Acute Lymphoblastic Leukemia samples
A set of 37 BCR-ABL positive (21 and 16 of which expressed p185 and p210, respectively) and 17 BCR-ABL negative adult ALL specimens from MRC UKALLXII/ECOG E2993 intergroup study. Gene expression profiling was performed using the 3DNA Array 900 Expression Array Detection Kit (Genisphere, Hatfield, PA...
ORGANISM(S): Homo sapiens 
2007-05-23 | E-SMDB-3750 | biostudies-arrayexpress
ProteomicsFunctional proteomics defines differential signaling networks of the oncogenic kinases Bcr-Abl p210 and p185
The two major isoforms of the oncogenic Bcr-Abl tyrosine kinase, p210 and p185, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p185 occurs in the majority of B-cell acute lymphoblastic leukemia. Differences in protein-prote...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-31 | PXD005149 | Pride
Leukemia Bcr-abl tyrosine kinase Interactome Silac Phosphoproteome 
ProteomicsDe novo BCR-ABL linear kinase motifs revealed by phosphoproteomics in yeast
Protein tyrosine phosphorylation (pY) is central to many cellular signaling pathways. Deregulation of pY can lead to malignancies such as leukemia. Thus, assigning kinase-substrate relations is imperative to understand disease alterations. However, such efforts are complicated by kinase redundancy, ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD038551 | Pride
Bcr-abl Ksea Phosphoproteomics Abl Linear sequence motif Protein tyrosine phosphorylation 
TranscriptomicsGene expression profiling in BCR/ABL-expressing LSCs and BCR/ABL-expressing Hif1a-/-LSCs
Using a mouse model of chronic myelogenous leukemia (CML), here we report that HIF1M-NM-1 plays a crucial role in survival maintenance of leukemia stem cells (LSCs). Deletion of HIF1M-NM-1 impairs the propagation of CML through impairing cell cycle progression and inducing apoptosis of LSCs. Deletio...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-35111 | biostudies-arrayexpress
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