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ProteomicsModulation of Intracellular Pathways of HIV-1 infected Macrophages exposed to Sigma-1 Receptor Antagonist (BD1047) prior to Cocaine and its Role in Cathepsin B Secretion revealed by Quantitative Proteomics
HIV-1 infects monocytes derived macrophages (MDM), that migrate into the brain, and secrete neurotoxic molecules, including cathepsin B (CATB). Cocaine potentiates CATB secretion. Pretreatment with BD1047, a sigma-1 receptor antagonist, before cocaine exposure, reduces infection, CATB secretion, and...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052318 | Pride
Monocyte-derived macrophages (mdm) Bd1047 Human immunodeficiency virus (hiv) Cocaine 
UnknownAnalysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics.
Not available
S-EPMC11428496 | biostudies-literature
UnknownSigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine.
Not available
S-EPMC6488453 | biostudies-literature
UnknownThe Sigma-1 Gene as a Prognostic Marker in Chemotherapy-Treated Breast Cancer-Antagonists' Synergism With Paclitaxel In Vitro.
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S-EPMC12611308 | biostudies-literature
UnknownInvolvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis.
Not available
S-EPMC8008527 | biostudies-literature
UnknownOxycodone protects cardiac microvascular endothelial cells against ischemia/reperfusion injury by binding to Sigma-1 Receptor.
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S-EPMC9161947 | biostudies-literature
UnknownEvaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET.
Not available
S-EPMC4170105 | biostudies-literature
UnknownSigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism.
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S-EPMC9221035 | biostudies-literature
UnknownNew positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects.
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S-EPMC4106900 | biostudies-literature
UnknownGenomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain.
Not available
S-EPMC8128747 | biostudies-literature
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