Sort   by:  
 Page size 
TranscriptomicsCocaine-regulated expression of striatal microRNAs
We cataloged miRNA expression in the nucleus accumbens and at striatal synapses in control and chronically cocaine-treated mice. We identified cocaine-responsive miRNAs, synaptically-enriched and depleted miRNA families, and confirmed cocaine-induced changes in protein expression for several predict...
ORGANISM(S): Mus musculus 
2011-05-13 | E-GEOD-29261 | biostudies-arrayexpress
TranscriptomicsCD4+ Tcell : control vs cocaine treated
Changes in miRNA profile of CD4+ T cells treated with cocaine 6 samples were analysed, 3 control and 3 treated with cocaine
ORGANISM(S): Homo sapiens 
2013-05-28 | E-GEOD-46398 | biostudies-arrayexpress
GenomicsEssential role of poly(ADP-ribosyl)ation in cocaine action
Many of the long-term effects of cocaine on the brain's reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin modifications, including histone acetylation and methylation, have been implicated in this regulation, but the effect of other histone modifica...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-55136 | biostudies-arrayexpress
TranscriptomicsStriatal microRNA controls cocaine intake through CREB signalling
MicroRNAs (miRNAs) regulate many basic aspects of cell biology including neuronal plasticity, but little is known of their roles in drug addiction. Extended access to cocaine can trigger the emergence of compulsive drug-seeking behaviors, but molecular mechanisms regulating this process remain uncle...
ORGANISM(S): Rattus norvegicus 
2010-07-08 | E-GEOD-21901 | biostudies-arrayexpress
GenomicsChIP-Seq reveals regulation of the heterochromatic mark, H3K9me3, in NAc following repeated cocaine administration
Repeated administration of the psychostimulant cocaine has been shown to produce persistent alterations in genome-wide transcriptional regulatory networks, chromatin remodeling activity and, ultimately, gene expression profiles in the brain’s reward circuitry. Virtually all previous investigations h...
ORGANISM(S): Mus musculus 
2011-01-18 | E-GEOD-24850 | biostudies-arrayexpress
TranscriptomicsEffects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Genetic association studies, pharmacological investigations and analysis of mice-lacking individual genes have made it clear that Cocaine administration and Withdrawal have a profound impact on multiple neurotransmitter systems. The GABAergic medium spiny neurons of the nucleus accumbens (NAc) exhib...
ORGANISM(S): Mus musculus 
2013-01-10 | E-GEOD-43410 | biostudies-arrayexpress
TranscriptomicsS-adenosylmethionine modifies cocaine-induced DNA methylation and increases locomotor sensitization in mice
The aim of the study was to investigate whether environmental factors like S-adenosylmethionine (SAM) via affecting epigenome could alter cocaine-induced gene expression and locomotor sensitization in mice. Using mouse nucleus accumbens (NAc) tissue, whole-genome gene expression profiling revealed t...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48365 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Promoter Analysis of Epigenetic Regulation by Cocaine (MM5 data)
Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction, however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupl...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-16183 | biostudies-arrayexpress
TranscriptomicsExpression profiling in dopaminergic brain structures of rats self-administering cocaine
Gene expression profiling in dopaminergic brain structures of rats self-administering cocaine. Effect of histone deacetylase inhibition We have shown that injection of the HDAC inhibitor trichostatin A (TsA) to rats is sufficient to decrease their motivation to self-administer cocaine. The aim of th...
ORGANISM(S): Rattus norvegicus 
2010-01-21 | E-GEOD-18055 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Promoter Analysis of Epigenetic Regulation by Cocaine
This SuperSeries is composed of the following subset Series: GSE16183: Genome-Wide Promoter Analysis of Epigenetic Regulation by Cocaine (MM5 data) GSE16184: Genome-Wide Promoter Analysis of Epigenetic Regulation by Cocaine (MM8 data) Refer to individual Series
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-15968 | biostudies-arrayexpress
Sort   by:  
 Page size