Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.

ABSTRACT: Genetic association studies, pharmacological investigations and analysis of mice-lacking individual genes have made it clear that Cocaine administration and Withdrawal have a profound impact on multiple neurotransmitter systems. The GABAergic medium spiny neurons of the nucleus accumbens (NAc) exhibit changes in the expression of genes encoding receptors for glutamate and in the signaling pathways triggered by dopamine binding to G-protein-coupled dopamine receptors. Deep sequence analysis provides a sensitive, quantitative and global analysis of the effects of Cocaine on the NAc transcriptome. RNA prepared from the NAc of adult male mice receiving daily injections of Saline or Cocaine, or Cocaine followed by a period of Withdrawal, was used for high-throughput sequence analysis. Changes w

ORGANISM(S): Mus musculus

SUBMITTER: Jodi Eipper-Mains 

PROVIDER: E-GEOD-43410 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress