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ProteomicsMolecular insights into mechanisms of GPCR hijacking by Staphylococcus aureus
We use hydrogen-deuterium exchange mass spectrometry (HDX-MS) to analyse the effects of S. aureus leucotoxins binding to the atypical chemokine receptor ACKR1 on receptor's structure and dynamics.
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus subsp. aureus NN50 
2021-11-03 | PXD027043 | Pride
Host-pathogen interactions Structural mass spectrometry Pharmacology Gpcr 
ProteomicsMultisite phosphorylation of intrinsically disordered region of Dishevelled
When WNT binds to its receptor Frizzled (FZD) to activate the signaling, Dishevelled (DVL), the central component of Wnt signaling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are k...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2026-04-07 | PXD063470 | Pride
Dishevelled Phosphorylation Hdx-ms 
ProteomicsConformational dynamics underlying Atypical Chemokine Receptor 3 activation
Here we used Hydrogen/Deuterium exchange mass spectrometry (HDX-MS) to examine the binding mode and mechanism of action of various small-molecule ACKR3 ligands of different efficacy for β-arrestin recruitment. Our results show that activation or inhibition of ACKR3 is largely governed by intracellul...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD044103 | Pride
Md Gpcr Hdx-ms 
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