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ProteomicsPKC Inhibition by GÖ6976 Promotes Osteogenic Differentiation of Dental Follicle Cells via Activation of RhoA GTPase Signaling
Dental follicle cells (DFCs) are promising candidates for regenerative medicine due to their osteogenic potential. While the protein kinase C (PKC) inhibitor Gö6976 is known to enhance DFC differentiation, the underlying molecular mechanisms remain partially understood. Methods: We performed a pho...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD081715 | Pride
Dental follicle cells  osteogenesis  protein kinase c  rhogtpase  sost  phosphoproteomics 
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-20 | PXD002214 | Pride
Type 2 diabetes artery proteomics 
ProteomicsCombined FGFR and Akt pathway inhibition abrogate growth of EGFR TKI-resistant NSCLC cells with upregulated FGFR1 expression
Introduction: The clinical benefit of EGFR tyrosine kinase inhibitor (TKI) treatment in non-small cell lung cancer (NSCLC) patients with activating EGFR mutations is temporary, as virtually all patients develop acquired EGFR TKI resistance that occurs via diverse mechanisms. Here, we identified incr...
ORGANISM(S): Homo sapiens (Human) 
2021-07-08 | PXD011803 | Pride
Akt inhibitors Shutgun proteomics 4-plex itraq 
ProteomicsProteomic analysis of renal biomarkers of kidney allograft fibrosis – a study in renal transplant patients
Renal transplantation is the preferred treatment of end stage renal disease, but allograft survival is limited by development of interstitial fibrosis and tubular atrophy in response to various stimuli. Much effort has been put into identifying new protein markers of fibrosis to support the diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD017867 | Pride
Nano-lc-msms Transplant Kidney fibrosis 
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort2
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008468 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort1
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008467 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsMigraine-associated mutation in the Na,K-ATPase leads to disturbances in cardiac metabolism and reduced cardiac function
Background. Mutations in ATP1A2 gene encoding the Na,K-ATPase α2 isoform is associated with familial hemiplegic migraine type 2 (FHM2). Migraine with aura is a known risk factor for heart disease. The Na,K-ATPase is important for cardiac function but its role for heart disease remains unknown. We hy...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-05-20 | PXD028952 | Pride
Heart failure Oxidant stress Gene expression and regulation Cell signaling Contractile function 
ProteomicsSpectral Library Search for Improved TMTpro Labelled Peptide Assignment in Human Plasma Proteomics
Clinical biomarker discovery is often based on the analysis of human plasma samples. However, the high dynamic range and complexity of plasma pose significant challenges to mass spectrometry-based proteomics. Current methods for improving protein identifications require laborious pre-analytical samp...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042546 | Pride
Peptide identification  plasma proteomics  spectral library search  tmtpro 
ProteomicsAffinity capture enrichment versus Affinity depletion: A comparison of strategies for increasing coverage of low abundant human plasma proteins
present study, we evaluated four small molecule affinity-based probes based on agarose-immobilized benzamidine (ABA), O-Phospho-L-Tyrosine (pTYR), 8-Amino-hexyl-cAMP (cAMP), or 8-Amino-hexyl-ATP (ATP) for their ability to remove high-abundant proteins such as serum albumin from plasma samples thereb...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD020727 | Pride
Affinity enrichment Depletion Human plasma 
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080848 | MassIVE
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